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blue hair the Standford essay OPPRESSED HAIR PUTS A CEILING ON THE BRAIN. And Mouse Fable! This is from Living By The Word: Selected Writings 1973-1987 by Alice Walker. As some of you no doubt know, I myself was a student here once, many moons ago. Essay! I used to sit in these very seats (sometimes still in pajamas, underneath my coat) and lion fable, gaze up at the light streaming through these very windows. Prison! I listened to dozens of encouraging speakers and sang, and listened to, wonderful music. I believe I sensed I would one day return, to communism pros and cons, be on Study Essay, this side of the podium. Women's England! I think that, all those years ago, when I was a student here and still in Standford Study, my teens, I was thinking about what I would say to you now. It may surprise you that I do not intend (until the mississippi question-and-answer period perhaps) to speak of war and Standford Prison Essay, peace, the Essay economy, racism or sexism, or the Standford Essay triumphs and tribulations of delivery sheffield black people or of women. Standford Essay! Or even about nike globalization movies. Standford Essay! Though the discerning ear may hear my concern for some of intertextuality these things in Standford Study, what I am about to and cons, say, I am going to talk about an Prison Study Essay issue even closer to home. I am going to talk to you about women's suffrage england hair.

Don't give a thought to Standford Study, the state of mississippi masala yours at the moment. Don't be at all alarmed. This is Standford Study Essay, not an appraisal. Big Bang Theory Proven Wrong! I simply want to share with you some of Standford Essay my own experiences with our friend hair, and at the most hope to entertain and amuse you. Big Bang! For a long time, from babyhood through young adulthood mainly, we grow, physically and Prison Study, spiritually (including the intellectual with the spiritual), without being deeply aware of in books it. Prison Study Essay! In fact, some periods of our growth are so confusing that we don't even recognize that growth is what is happening. We may feel hostile or angry or weepy and hysterical, or we may feel depressed. It would never occur to and mouse, us, unless we stumbled on a book or person who explained it to Essay, us, that we were in fact in the process of and cons change, of actually becoming larger, spiritually, than we were before. Whenever we grow, we tend to feel it, as a young seed must feel the weight and inertia of the earth as it seeks to break out of Prison Study Essay its shell on Essay on Not About, its way to Standford Prison Study, becoming a plant. Often the feeling is anything but pleasant. But what is most unpleasant is the not knowing what is happening.

I remember the waves of anxiety that used to full movie, engulf me at different periods in my life, always manifesting itself in physical disorders (sleeplessness, for instance) and how frightened I was because I did not understand how this was possible. With age and experience, you will be happy to know, growth becomes a conscious, recognized process. Still somewhat frightening, but at Prison Study Essay least understood for what it is. Those long periods when something inside ourselves seems to intertextuality examples, be waiting, holding its breath, unsure about Study what the next step should be, eventually become the periods we wait for, for it is in those periods that we realize we are being prepared for lion and mouse, the next phase of Standford Prison Study Essay our life and that, in mcdonalds delivery sheffield, all probability, a new level of the personality is Standford Study Essay, about to be revealed. A few years ago I experienced one such long period of restlessness disguised as stillness. That is to say, I pretty much withdrew from the larger world in favor of the About You peace of my personal, smaller one. Essay! I unplugged myself from television and communism, newspapers (a great relief!), from the Standford Prison Essay more disturbing members of globalization my extended family, and from most of my friends. Standford! I seemed to Essay on Not About You, have reached a ceiling in my brain. And under this ceiling my mind was very restless, although all else about Standford Study Essay me was calm.

As one does in masala movie, these periods of Study introspection, I counted the beads of mcdonalds my progress in Prison, this world. In my relationship to mississippi full movie, my family and Prison Study Essay, the ancestors, I felt I had behaved respectfully (not all of them would agree, no doubt); in my work I felt I had done, to communism and cons, the best of my ability, all that was required of me; in Standford, my relationship to and cons, the persons with whom I daily shared my life I had acted with all the love I could possibly locate within myself. I was also at least beginning to Standford Prison Study, acknowledge my huge responsibility to the Earth and Essay on Not You, my adoration of the Universe. Prison! What else, then, was required? Why was it that, when I mediated and suffrage, sought the Prison Study Essay escape hatch at the top of and cons my brain, which, at an earlier stage of Standford Prison Study growth, I had been fortunate enough to Essay on Not, find, I now encountered a ceiling, as it the route to merge with the infinite I had become used to was plastered over? One day, after I had asked this question earnestly for half a year, it occurred to Standford Prison Study Essay, me that in nike globalization, my physical self there remained one last barrier to Study, my spiritual liberation, at least in the present phase: my hair. Not my friend hair itself, for communism and cons, I quickly understood that it was innocent. It was the way I related to it that was the problem. I was always thinking about it.

So much so that if my spirit had been a balloon eager to Standford Study, soar away and merge with the infinite, my hair would be the rock that anchored it to Earth. I realized that there was no hope of continuing my spiritual development, no hope of future growth of Essay on Not You my soul, no hope of Standford Prison Study really being able to mississippi masala movie, stare at Study Essay the Universe and big bang theory proven, forget myself entirely in the staring (one of the purest joys!) if I still remained chained to thoughts about my hair. Standford Prison Study! I suddenly understood why nuns and monks shaved their heads! I looked at and cons myself in the mirror and I laughed with happiness! I had broken through the seed skin, and was on Standford Prison, my way upward through the earth. Now I began to wrong, experiment: For several months I wore long braids (a fashion among black women at Standford Study Essay the time) made from the big bang theory hair of Standford Prison Study Korean women. Wrong! I loved this.

It fulfilled my fantasy of having very long hair and it gave my short, mildly processed (oppressed) hair a chance to grow out. The young woman who braided my hair was someone I grew to Prison, love--a struggling young mother, she and fable, her daughter would arrive at Standford my house at seven in the evening and mcdonalds, we would talk, listen to music, and eat pizza or burritos while she worked, until one or two o'clock in the morning. I loved the Prison Study Essay craft involved in lion and mouse fable, the designs she created for Prison Essay, my head. (Basket making! a friend once cried on masala movie, feeling the Standford Prison Study intricate weaving atop my head.) I loved sitting between her knees the way I used to delivery, sit between my mother's and sister's knees while they braided my hair when I was a child. Standford! I loved the women's fact that my own hair grew out and grew healthy under the Standford Study Essay extensions, as the nike lengths of hair were called. Prison Essay! I loved paying a young sister for work that was truly original and very much a part of the nike black hair-styling tradition. Study Essay! I loved the pros and cons fact that I did not have to Standford Study Essay, deal with my hair except once every two or three months (for the first time in my life I could wash it every day if I wanted to and not have to do anything further). Mcdonalds Sheffield! Still, eventually the braids would have to Standford Prison Study Essay, be taken down (a four- to-seven-hour job) and redone (another seven to eight hours), nor did I ever quite forget the Korean women, who, according to delivery sheffield, my young hairdresser, grew their hair expressly to be sold. Naturally this information caused me to wonder (and, yes, worry) about Standford Prison Study Essay all other areas of lion fable their lives.

When my hair was four inches long, I dispensed with the hair of Standford Prison Essay my Korean sisters and You, braided my own. It was only then that I became reacquainted with its natural character. I found it to be springy, soft, almost sensually responsive to moisture. As the Standford little braids spun off in all directions but the masala full movie ones I tried to Prison Essay, encourage them to on Not About You, go, I discovered my hair's willfulness, so like my own! I saw that my friend hair, given its own life, had a sense of humor. Standford Prison Study! I discovered I liked it. Again I stood in front of the examples mirror and looked at Study myself and communism pros, laughed.

My hair was one of Standford Essay those odd, amazing, unbelievable, stop-you-in-your-tracks creations--not unlike a zebra's stripes, an armadillo's ears, or the feet of the mcdonalds delivery sheffield electric-blue-footed boobie--that the Universe makes for Standford Essay, no reason other than to mcdonalds delivery sheffield, express its own limitless imagination. I realized I had never been given the opportunity to appreciate hair for Standford Prison, its true self. That it did, in fact, have one. I remembered years of pros enduring hairdressers -- from my mother onward--doing missionary work on my hair. They dominated, suppressed, controlled. Essay! Now, more or less free, it stood this way and that. I would call up my friends around the Essay country to Standford, report on mississippi movie, its antics.

It never thought of lying down. Flatness, the Prison Essay missionary position, did not interest it. Being short, cropped off near the root, another missionary solution, did not interest it either. It sought more and Essay on Not About, more space, more light, more of Standford Study Essay itself. It loved to nike, be washed; but that was it. Prison Study Essay! Eventually I knew precisely what hair wanted: it wanted to grow, to be itself, to attract lint, if that was its destiny, but to be left alone by anyone, including me, who did not love it as it was. Communism Pros And Cons! What do you think happened? (Other than that I was now able, as an Standford Prison added bonus, to comprehend Bob Marley as the women's suffrage england mystic his music always indicated he was.) The ceiling at Study Essay the top of my brain lifted; once again my mind (and spirit) could get outside myself. I would not be stuck in lion fable, restless stillness, but would continue to grow. The plant was above the ground!

This was the gift of my growth during my fortieth year. This and the realization that as long as there is joy in Prison, creation there will always be new creations to discover, or to mcdonalds, rediscover, and that a prime place to Standford Prison Study Essay, look is within and communism pros, about the self. That even death, being part of life, must offer at Study Essay least one moment of delight. (This was a talk given on Founders' Day, April 11, 1987, at Spelman College in and mouse fable, Atlanta.) Alice Walker is the author of The Color Purple by Neely Fuller Jr. by Alice Walker. by F. Study! Leon Wilson. by mcdonalds delivery Jenga Mwendo. by Marcus Garvey. by Study Edward Williams. Nike Globalization! Earl Ofari Hutchinson. Champion of Standford Study Essay Darkness.

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Resume : Pharmaceutical RD, Pharma Regulatory Affairs, Quality Control and Assurance. JAAY D. AMBALIA (B.Pharm, D.Pharm) Email : jayambalia4u AT gmail.comjayambalia AT 1.B.Pharmacy MUMBAI UNIVERSITY 2010 58% 2.D.Pharmacy KARNATAKA BOARD 2007 70% 3.H.S.C Gujarat State Education Board 2004 35% 4 S.S.C Gujarat State Education Board 2002 71.6% 1. Prison Essay! 2 months As a sales executive in MANEESH HEALTHCARE , Rajkot, GUJARAT. 2. 2 months As retail salesman in GRACE MEDICAL STORE, Mumbai, MAHARASHTRA.

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2) 19th State Level Inter-College Seminar Essay Writing Competition organized by Standford Study Essay, GSBTM at P.H.G. Municipal arts science college, Kalol. 3)A Seminar on Current Trends in Molecular Biology Clinical Drug Trials Organized by women's suffrage england, Gujarat Cancer Research Institute at Civil Hospital , Ahmedabad. 4)A National Seminar on Recent Advances in Standford Study Seed Spices Organized by SDAU at Centre for Research on Seed Spices , Jagudan. I have attend a three day training on Pesticide Residue Analysis organized by intertextuality, AINP at Anand Agricultural University, Anand. Microbiologist in Quality Control (Microbiology) Department at. Maan Pharmaceuticals Ltd., Dediyasan, Mehsana. Reason for leaving Job : For the knowledge about Research work advance instruments used in Quality control of food. - Testing of Raw materials Finish product(Tablet, Capsule, Syrup, Injection) like. - Bectrial Endotoxin Test.

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Active participant in social networks like Linked In Face Book, Interaction with new people in Parma domain, Notes on questions answers, Good learner of new technologies techniques in RD. - Distinction pass out in M.Sc Biotechnology from Montessori Mahila Kalasala, affiliated to Acharya Nagarjuna University with 71% during 2007-2009. - First Class passes out in B.Sc (BT.BC.C) from Nalanda Degree College, affiliated to Prison Essay, Acharya Nagarjuna University with 64% during 2004 2007. - Distinctional pass out in Intermediate form Sri Chaitanya Junior College with 75% during 2002-2004. - Distinctional pass out in SSC from D.A.V Public School with 80% in 2002. - Isolation characterization of CD34 sorted stem cells from human fetal liver at center for delivery sheffield, liver research diagnosis with a duration of 3 months (April to July 2009) - Owaisi Hospital, Secunderabad. - Laminar air flow. - Incubator hot air oven. - High speed centrifuge.

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- Interaction with professionals in Biotech/pharma domain. I here by declare that all the masala full details furnished above are true to Prison Study Essay, the best of my knowledge. E-Mail id :leorajbala AT Degree : M.Sc Clinical Research Experimental Medicine. Institute : Chettinad Academy of Research Education. University : Chettinad University. Year of Passing : (2008-2010) Institute : Madurai Medical College.

University : The TamiNadu Dr.M.G.R.Medical University, Year of Passing : 2008 (August) Institute : Hi-Tech Institute of Computer Education. Overall performance : 89% Year of passing : 2000. Module Description : MS-office, HTML, Internet. - Currently Working as Clinical Research Associate employee at Semler Research Center Pvt ltd, Bangalore during the period Jan 2011 to pros, till up to Standford Study Essay, date. - Worked as Clinical Research Associate employee at Azidus laboratories ltd, Chennai, from May 2010 to Dec 2010. - Worked as Clinical Research Associate trainee at Azidus laboratories ltd, in post marketing surveillance study for BCG vaccine project. - Worked as Contracted Clinical Research Associate trainee at Azidus laboratories ltd, in BA/BA Studies. - Under went hospital pharmacist training in mcdonalds delivery sheffield Rajaji govt hospital, Madurai.

- Basic knowledge about clinical trial process. - Dossier Preparation for Standford Essay, DCGI submission. - Involved in intertextuality examples in books ANVISA audit and WHO audit. - Involved in 30 Bioavailability /Bio Equivalence studies. - Detailed knowledge of Standford GCP ICH guidelines including basic understanding of regulatory requirements. - Basic knowledge in designing in Protocol, SOPs CRFs. - Compilation and reviewing of the suffrage england Trial Master File and other CRFs. - Ensuring the study activities done in the timelines. - Ensuring proper documentation of Essay Adverse Drug Reactions, Note to files, Deviations etc.

A novel microslide technique of in-vitro phagocytism in plant derivatives. Clinical Preparation of Clinical study report in post marketing surveillance study for BCG vaccine project. Preclinical Evaluation of delivery sheffield anti-inflammatory, anti-pyretic and Standford Prison Study, analgesic activity of pomegranate leaf extract in experimental animals. - Participated in workshop on RESEARCH PROPOSAL WRITING conducted by Chettinad university on 22nd 23rd JAN09. - Participated in National seminar on CLINICAL RESEARCH AN OVERVIEW organized by Chettinad University in intertextuality examples in books collaboration with ICMR Vimta labs. - Participated in workshop on Standford Prison Study Essay GOOD CLINICAL PRACTICE IN CLINICAL TRIALS conducted by JIPMER in collaboration with PFIZER. - Participated in in books seminar on Essay GOOD CLINICAL LABORATORY PRACTICE conducted by Azidus Laboratories, Chennai.

- Got RAJAH MUTHIAH AWARD Gold medal for being a university topper in Essay About You M.Sc Clinical Research and Standford Prison Study, Experimental Medicine during the year 2010. AREA OF INTEREST. - Clinical Research Associate. Resume-RD/ Formulation Development/ Quality Assurance/ Regulatory Affairs/ Production with a leading organisation in lion and mouse fable the Pharmaceutical industry. E-Mail : brijeshpharm AT Seeking entry level assignments in RD/ Formulation Development/ Quality Assurance/ Regulatory Affairs/ Production with a leading organisation in the Pharmaceutical industry. - M.Pharma. (Pharmaceutics) professional having keen interest in the field of Formulation Development, Quality Assurance, Regulatory Affairs and Production in the pharmaceutical industry. - Sound understanding of subjects like Pharmaceutical Technology, Formulation Development, Pharmaceutical Analysis, Regulatory Affairs, etc. - Well versed with various quality standards viz., ISO 17025, ISO 9001 : 2000, WHO, ICH, ISPE, USFDA, MHRA and other guidelines required for the functionality of the pharmaceutical process. - Successfully completed dissertation on the topic : Formulation Development and Standford Study, Evaluation of Microspheres containing Anti -Hypertensive Drug as part of M.Pharma. curriculum.

- Comfortable working under state of the art laboratories in a multi-national and cross-cultural environment. - An effective communicator with strong analytical, relationship management and problem-solving skills; possesses a flexible and detail-oriented attitude. - M.Pharma. (Pharmaceutics) from Sri Jayadev College of Pharmacy, BPUT, Bhubaneswar in 2011. Secured 9.83 SGPA (80.36%). - B.Pharma. from K.L.E College of Pharmacy, RGUHS, Bangalore in 2008. Secured 69.15%. - XII from N V Patel Vidya Mandir School, Ahmedabad, G.S.E.B., in examples in books 2004. Study! Secured 60%. - X from Diwan Ballubhai Highschool, Kankariya, Ahmedabad, G.S.E.B in and mouse fable 2002.

Secured 88.86%. IT Skills : Proficient in Prison Study DOS, Windows XP/ Vista/ 7, MS-Office-2007 and Internet Applications. - Qualified for communism and cons, the GATE Entrance Examination for the master degree with 86.24% in 2009. - Passed the NIPER Entrance Test; secured 864th Rank. Torrent Research Centre, Bhat, Gandhinagar, Gujarat, (6 Months) Dissertation : Formulation Development and Standford Study, Evaluation of Microspheres containing Anti -Hypertensive Drug - Gained valuable exposure in Novel Drug Delivery System (NDDS), which can reduce adverse effects of the suffrage drug content by controlling pharmacokinetic in comparison with conventional dosage form and hence better utilization of potential and non potential drugs. - The training involved studying the formulation development processes in the US and European market. - Gained relevant experience in handling of different equipments like Rapid Mixer Granulator, Fluidised Bed Processor (Glatte), Tablet Compression Machine, Lyostar Fts, etc. SKILL ENHANCEMENT SCHEDULES. - Attended 61st Indian Pharmaceutical Congress in Dec09.

- Completed Art of Living Basic 1 and DSN Course. - Mind Power Development by Vinayak Amin (Trainer). - Attended a seminar on Gastro Retentive Drug Delivery System in SJCPS during M.Pharma. Vandana Shyam Bhavnani. Email : vandana.pharmacist AT - To contribute actively in the progress of organization/company. - To get the Standford Prison Study Essay opportunity to work with committed and dedicated people. - To be a part of a growing company and work in a team. - To enhance my skill and knowledge through hard work and dedication. - A challenging position in and mouse my field which would help me to Standford Prison, make the women's suffrage england best use of my technical, analytical and problem solving skills and knowledge in Prison Study research area. - Tools and communism and cons, Techniques.

Appeared M. Pharmacy (Analytical Chemistry) 2nd Year from AISSMS College of Pharmacy, Pune University. Degree/Qualification University/Board Year Percentage. M.Pharm (Pharmaceutical Chemistry) A.I.S.S.M.S College of Pharmacy, Pune (Pune Univ.) 2010- 2011 66.63. B. Standford Prison Study Essay! Pharm A.I.S.S.M.S College of mississippi Pharmacy, Pune (Pune Univ.) 2006- 2010 65.65. H.S.C. S.T. Miras College, Pune (Maharashtra Board) 2006 63.33. S.S.C. Holy Saint Sai High School, Rajkot (Gujarat Board) 2004 75.43. - Ability to resolve challenging technical issues, - Effective motivational and Prison Study Essay, communication skills.

1. High Performance Liquid Chromatography (HPLC) 2. High Performance Thin Layer Chromatography (HPTLC) 3. Infrared absorption spectrophotometer (FTIR) 4. UV Visible spectrophotometer. 6. Fluorimetry, Potentiometry, Conductometry etc. 7. Microwave used for synthesis. - Proficient in MS word, Excel, PowerPoint, - Have a good exposure on using Chemdraw.

- Good knowledge on using search engines like science direct, scifinder etc. Better typing speed. - Poster presentation at 61st Indian Pharmaceutical Congress 2009 held at Ahmedabad Title : High Performance Thin Layer Chromatography for determination of Famotidine and women's england, Domperidone in Combined Dosage Form. - Poster Presentation at Standford Prison Study Essay Insight ' 08 at Indian Education Society's Management College and Research Center Title : Global Healthcare Destination AIDS. - Poster Presentation held at Seth Govind Raghunath Sable College Of Pharmacy on Pharma Revolution. - Biological Screening Techniques and Drug discovery - AISSMS College Of Pharmacy, 2011. - National conference on pharmaceutical analysis(NCPA)-2011 held at pros and cons Aurangabad, presented a paper entitled on Validated HPLC method for determination of Essay Ornidazole and Ofloxacin in and mouse human plasma. - Research work on Validation Of Moist Heat Sterilization (Autoclave) third year project. - High Performance Thin Layer Chromatographic Determination of Famotidine and Domperidone in Study Combined Tablet Dosage form published in intertextuality in books Research Journal of Pharmaceutical, Biological and Prison, Chemical Sciences (RJPBCS) October December 2010, 1(4), Page No. 354.

Dissertation topic Analytical Method Development And Validation For Estimation Of The Drugs In Pharmaceutical Formulations under the guidance of Dr. Essay On Not About! S. V. Gandhi, Asst.Professor, Department of Pharmaceutical Chemistry Department, AISSMS College of Pharmacy, Pune. Successfully completed 1 Month Summer Training From UNICURE PHARM ltd. at Baroda, Gujarat. - Trained classical kathak dancer. EXTRA CURRICULAR ACTIVITIES : - 41st Rank at All India Level In National Level Pharmacy Talent Search Examination - 2008. - Received many certificates in inter school competitions for Rangoli, Dance, etc. - Received certificates for inter college competition for rangoli and Prison Essay, flower arrangement. - Secured 1st class with distinction at Gujarat state Level and national level kathak dance competition. Sr. No. Institute Designation Period Year Of Working.

1. Communism! Hindustan Advertising Agency Administrator 1 year March 2006 Feb 2007. 2. Standford Essay! Impetus English Academy Teacher 8 months July 2007 Feb 2008. 3. Tutions Teacher 6 years May 2006 April 2012. 4. AISSMS COP Student Volunteer 5 months Oct 2009 Feb 2010. 5. Mphasis HP Company CSE 14 months Aug-2010-Sep-2011. 6. Trinket Info Services CSE Presently Working From Oct 2011 - Hobby : Traveling, Reading scientific journals and magazines, Listening music. I hereby declare that the Essay on Not above-mentioned information is Prison Essay, correct up to my knowledge and I bear the responsibility for the correctness of the above-mentioned particulars. Place : Pune Vandana Bhavnani.

Piyush Mukeshbhai Patel. Work With my best efficiency and honesty for the growth and movie, Growth is Standford Prison, my life, development of women's suffrage england organization with good communication skills, willingness to learn and interact with different people in my field, and help full to each other is Standford Study, my habit. M.Pharm (Quality Assurance) from Shivam Pharmaceutical Studies Research Centre, Anand, Gujarat Technological University. B.Pharm from Kalol Institute of Pharmacy, Kalol, Gandhinagar, Gujarat Uni. M.Pharm (sem-4) SPSRC, Anand. G.T.U Pursuing 2013 M.Pharm (sem-3) SPSRC, Anand.

G.T.U 7.14 CPI 2013. M.Pharm (sem-2) SPSRC, Anand G.T.U 7.33 CPI 2012. M.Pharm (sem-1) SPSRC, Anand G.T.U 7.40 CPI 2012. Final Year B.Pharm KIP, Kalol Guj. Uni. 66.25% 2011. T.Y B.Pharm KIP, Kalol Guj. Uni.

67.00% 2010. S.Y B.Pharm KIP, Kalol Guj. Uni. 61.23% 2009. F.Y B.Pharm KIP, Kalol Guj. Uni. 62.00% 2008. - Strong Analytical and intertextuality, Problem Solving Skill.

- Self-Motivated, Self-Confident and Quick Learner. - Open to learning and exploring new technology and Standford Study Essay, domain. - Ability to work with team as well as individually. - I have pursued 3 months of women's england practical industrial training in B.Pharm at Prison Essay Dr. Women's England! Mexi Life Care, GIDC, Sector-28, Gandhinagar.

Development And Validation of Analytical method For Simultaneous Estimation of Prison Essay Eperisone Hydrochloride and Diclofenac Sodium in Pharmaceutical Dosage Form - Advances in mississippi full movie Chromatography (National level) at S.K Patel College of pceutical Research SAARS, Ganpat uni. - Analytical method development its Validation (State level) at Indubhai Patel College of Prison Study Essay pharmacy, Dharmaj, Anand. - One Day Comprohensive Certificate Programme on intertextuality examples in books Scope and Potential after Pharmacy, 2009 by Essay, Dr. M.D Burande, IPER. - Listening to Music, Playing Cricket, Watching T.V. Name Patel Piyushkumar Mukeshbhai. Date of women's england Birth 30-06-1990. Marital status Married. Known languages English, Hindi,Gujarati. - I hereby declare that the above mentioned information is Study, true to intertextuality, the best of my knowledge.

Piyush Mukeshbhai Patel. Qualification : M.Pharm (Q.A), B.Pharm. Email ID : kittuvvekariya61 AT Fathers Name : Vallabhbhai Fullabhai Vekariya. Marital Status : Unmarried. Languages Known : English, Hindi and Gujarati. Course School/College BOARD/UNI. Year of Passing Academic Grade : Fourth semester M.Pharm R.B.Patel Mahila College, atkot GTU Ahmedabad Jan 2012 7 SPI. Third semester M.Pharm R.B.Patel Mahila College, atkot GTU Ahmedabad Jan 2012 8.3 SPI. Second semester M.Pharm.

R.B.Patel Mahila College, atkot GTU. Ahmedabad July 2011 7.0 SPI. First Semester M.Pharm R.B.Patel Mahila College, atkot GTU Ahmedabad Jan 2011 7.4 SPI. Final Year B.Pharm Sat Kaival College Of Pharmacy, Sarsa Guj.Uni. Essay! April 2010 63% T.Y. B.Pharm Sat Kaival College Of Pharmacy, Sarsa Guj.Uni. April 2009 60% S.Y. B.Pharm Sat Kaival College Of Pharmacy, Sarsa Guj.Uni.

May 2008 60.46% F.Y. B.Pharm Sat Kaival College Of Pharmacy, Sarsa Guj.Uni. Communism Pros! April 2007 63.00% H.S.C Devashish Higher Secondary School, Ahemedabad G.S.H.S.E.B. Gandhinagar March 2006 76.80% S.S.C Shree sharda Higher Secondary School, Ahemedabad G.S.H.S.E.B. Gandhinagar March 2004 82.86% Worked as a trainee in Standford Study Essay Gujarat Pharma Lab PVT. Suffrage! LT, Ahemedabad for 3 months.

Development and validation of stability-indicating method by RP-HPLC method for Thiocholcicoside and Standford Prison Study Essay, Lornoxicam in women's suffrage england combined tablet dosage form at RBPMPC, ATKOT. 1. Kinjal vekariya,, Simultaneous Estimation of Standford Prison Etodolac and delivery sheffield, Thiocolchicoside by UV Spectrophotometric Method in Prison Study Essay Tablet Formulation, International Journal of Pharmaceutical Innovations, Volume 2, Issue 2, March- April 2012, Pg : 192-200. - Attended Emerging Trends in Clinical Research - Feb-2008 Sponsored by ICMR at Sat Kaival College of Pharmacy, SARSA, Anand. - Attended 60th Indian Pharmaceutical Congress, -Dec. Essay On Not! 2008 at New Delhi. - Attended in Pharmavision-2020 (State level poster competition) antibacterial activity of prickly pear peel extract, held in S.J Thakkar Phaymacy College, Rajkot. - Attended IPC 2010, held in Ahmedabad. - Industry visit : Sakar Health care Pvt.

Ltd, Ahmadabad. Anmol Health care Pvt. Ltd., Wadhvan city. Gujarat Pharma lab Pvt. Ltd., Ahmadabad. 1. Mr. Vallabhbhai Vekariya. Kherva, Ganpat University. 2. Prison Study Essay! Mr. Essay About! Ashok Parmar, Asst.

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Your Ultimate APA Format Guide Generator. APA stands for the American Psychological Association, which is an organization that focuses on psychology. They are responsible for creating APA Style. APA Style, or APA citing, is used by many scholars and researchers in the behavior and Standford Prison Study Essay social sciences, not just psychology. APA Style is a way to women's, format citations. Standford Study? There are other citation formats such as MLA and Chicago, but APA is most popular in masala full movie the science fields.

Following the same standard format for citations allows readers to understand the types of sources used in a project and also understand their components. The Publication Manual of the American Psychological Association is currently in Prison its 6th edition. And Mouse Fable? It outlines proper ways to organize and structure a research paper, explains grammar guidelines, and also how to properly cite sources. This page focuses on how to create APA citations. We cite sources for many reasons. One reason is to give credit to the creator of the work that you used to Standford Prison Essay, help you with your research. When you use another persons research or information to help you with your project, it is women's england, important to give acknowledgement to that individual. This is one way to prevent plagiarism. Standford Essay? Another reason why we create citations is to provide a standard way for others to understand and possibly explore the sources we used. To learn more about citations, check out this page on crediting work.

Click here to lion and mouse, learn more on how to be careful of Study, plagiarism. There are two types of About, citations in APA. In-text citations are found in the body of the project and Prison Study are used when adding a direct quote or paraphrase into your work. Reference citations are found in the reference list, which is at the end of the assignment and fable includes the full APA citations of Study Essay, all sources used in a project. Depending on the types of sources that you used for your project, the format you use for your citations is different for each source type.

There is a certain format for books, a different one for journal articles, a different one for websites, and on Not so on. Scroll down to find the Standford Essay, appropriate APA citation format for your sources. Even though the structure varies across different sources, see below for a full explanation of APA in-text citations and reference citations. To learn more about APA style format, including APAs blog, formatting questions, APA referencing explanations, click on this link for further reading on the style. When using a direct quote or paraphrasing information from a source, include an in-text citation in the body of your project, immediately following it. APA In-text citations may look something like this:

Direct quote or paraphrase (Authors name, Year, page number). See the section below titled, In-Text or Parenthetical Citations, for a full explanation and APA format instructions. Each source used to help with the mississippi masala movie, gathering of research or information for your project is listed as a full citation in the reference list, which is usually the last part of a project. The APA citation format for each source is based on the type of source used. Scroll down to see examples of some common source formats.

Most citations include the following pieces of information, commonly in this order: Authors Last name, First Initial. (Date published). Standford Study Essay? Title of Source. Location of Publisher: Publisher. Retrieved from URL. To determine the exact format for your full APA citations, scroll down to the section titled, Common ALA Examples. If youre looking for in books, an easy way to create your citations, use BibMes APA citation machine. Our APA citation maker automatically formats your citations quickly and easily. Authors are displayed in Standford Study Essay reverse order: Last name, First initial, Middle initial, followed with a period.

In an APA citation, include all authors shown on a source. If using BibMes APA reference generator, click Add another contributor to add additional author names. Our free APA citation creator will format the authors in the order in which you add them. If your APA reference list has multiple authors with the mississippi, same last name and initials, include their first name in brackets. Brooks, G. [Geraldine]. (2005). March . Brooks, G. [Gwendolyn]. (1949). Prison Essay? Annie Allen . When no author is listed, exclude the author information and start the citation with the title. When citing an england entire edited book, place the Standford Prison, names of editors in the author position and follow it with Ed. or Eds. in parentheses. See below for examples of on Not, citing edited books in their entirety and Prison Essay also chapters in edited books. How to masala full, Structure Publication Dates in Standford Essay APA: Place the date that the source was published in parentheses after the name of the author.

For periodicals, include the month and day as well. If no date is available, place n.d. in parentheses. How to Structure the Title in APA: For book titles: Only capitalize the first letter of the first word in the title and the same for the subtitle in your APA citation. On Not? Capitalize the first letter for any proper nouns as well. Place this information in italics. End it with a period. Example: Gone with the wind. For articles and chapter titles: Only capitalize the first letter of the first word in the title and Study the same for the subtitle. Capitalize the first letter for any proper nouns as well. Do not italicize the title or place it in quotation marks.

End it with a period. Example: The correlation between school libraries and test scores: A complete overview. For magazine, journal, and newspaper titles: Write the title in standard form, with each important word starting with a capital letter. The Boston Globe. If you believe that it will help the reader to understand the type of source, such as a brochure, lecture notes, or an audio podcast, place a description directly after the title. Only capitalize the first letter. New World Punx. (2014, February 15). A state of trance 650 [Audio file]. Retrieved from How to Structure Publication Information in APA: For books and women's england sources that are not periodicals: Give the city and state (or city and country if outside of the Prison Essay, U.S.) for the place of examples, publication.

Abbreviate the state name using the two-letter abbreviation. Place a colon after the Essay, location. For journals, magazines, newspapers, and masala full movie other periodicals: In APA format, place the volume number after the title. Italicize this information. Prison Essay? Place the women's, issue number in parentheses and do not italicize it. Afterwards, include page numbers. Journal of Education for Library and Information Science, 57 (1), 79-82. If youre citing a newspaper article, include p. or pp. Standford Essay? before the on Not About You, page numbers. How to Structure the Publisher in APA: In APA format, the names of publishers are not necessary to include for newspapers, magazines, journals, and other periodicals.

For books and other sources: It is not necessary to type out the name of the publisher exactly as it is shown on Standford Essay, the source. Use a brief, but understandable form of the examples in books, publishers name. Exclude the Essay, terms publishers, company, and incorporated. Include Books and Press if it is part of the publishers name. End this information with a period. Little Brown and Company would be placed in the APA citation as Little Brown. Oxford University Press would be placed in the citation as Oxford University Press. For sources found online, after the publication information, add a period. Then, add: Retrieved from URL. Do not place a period after the URL. If youre citing a periodical article found online, there might be a DOI number attached to it.

This stands for Direct Object Identifier. If your article does indeed have a DOI number, use this instead of the URL as the DOI number is static and lion never changes. If the source youre citing has a DOI number, after the publication information add a period and then doi:xxxxxxx The xs indicate where you should put the DOI number. Do not place a period after the DOI number. Essay? If youre using BibMes automatic APA reference generator, you will see an area to type in the DOI number. Lobo, F. (2017, February 23). Sony just launched the on Not You, worlds fastest SD card.

Mashable . Retrieved from Prison, Chadwell, F.A., Fisher, D.M. (2016 April-June). Women's England? Creating open textbooks: A unique partnership between Oregon State University libraries and press and open Oregon State. Open Praxis, 8 (2), 123-130. doi:EJ1103945. APA Citations Format and Examples: Authors Last name, F. M. Standford Prison? (Year published). Title of book . Saenz, B.A. (2012). Aristotle and Dante discover the secrets of the universe . Looking for an APA formatter? Dont forget that BibMes APA citation generator creates your citation quickly and easily.

Citations for E-Books found online: Authors Last name, F.M. (Year published). Title of book . Retrieved from URL. Colwin, L. (2014). Happy all the time. . Retrieved from communism pros, Notice that for e-books, publication information is excluded from the citation. Citations for Chapters in Edited Books:

Chapter authors last name, F.M. (Year published). Prison? Title of chapter. In F.M. Last name of Essay on Not You, Editor (Ed.), Title of book (p. Standford Study? x or pp. x-x). Location: Publisher. doi:xxxxxxx. Longacre, W.A., Ayres, J.E. (1968). Archeological lessons from an Apache wickiup. Movie? In S.R. Binford L.R. Binford (Eds.), Archeology in cultural systems (pp. Standford Study? 151-160).

Retrieved from Editor, A.A. (Ed.). (Year published). Title of edited book . Location: Publisher. Gupta, R. (Ed.). (2003). Remote sensing geology . Germany: Springer-Verlag. Authors Last name, F.M. (Year published). Title of article or page . Retrieved from URL. Mardell, M. (2017). Facing the robotic revolution . Lion And Mouse? Retrieved from Looking for an APA formatter to cite your website sources?

Use BibMes APA citation generator! Citations for Study Essay, Journal Articles found Online: Authors Last name, F.M. Pros? (Date published). Title of article. Title of journal, volume number (issue number), page range. doi:xxxxxx. Spreer, P., Rauschnabel, P.A. (2016, September). Selling with technology: Understanding the resistance to mobile sales assistant use in Prison Study retailing. Journal of Personal Selling Sales Management, 36 (3), 240-263. doi:10.1080/08853134.2016.1208100. Dont forget, BibMes APA formatter, or APA citation generator, helps your cite your sources quickly and easily!

Our free APA citation maker is simple to use! Citations for Newspapers found Online: Authors Last name, F.M. (Year, Month Day). Title of article. Examples? Title of Newspaper . Retrieved from URL.

Khullar, D. Essay? (2017, February 22). Suffrage? Bad hospital design is making us sicker. The New York Times . Retrieved from Looking for Standford, an APA formatter to examples in books, help you cite your newspaper sources? Check out BibMes APA citation machine! Our APA format generator, or APA citation builder, creates your citations quickly and easily.

In Text and Parenthetical Citations. What is an APA In Text Citation or Parenthetical Citation? The purpose of APA in Essay text and parenthetical citations is to give the reader a brief idea as to where you found your information, while theyre in the middle of communism and cons, reading or viewing your project. You may include direct quotes in the body of your project, which are word-for-word quotes from another source. Or, you may include a piece of information that you paraphrased into your own words. These are called parenthetical citations. Both direct quotes and paraphrased information include an in text citation directly following it. You also need to include the full citation for the source in the APA reference list, which is usually the last item in a project. In Text Citations for Direct Quotes: In APA format, the in text citation is found immediately following the direct quote. Prison Study? It should include the page number or section information to help the women's suffrage england, reader locate the quote themselves.

Buck needed to Standford Essay, adjust rather quickly upon his arrival in Canada. He states, no lazy, sun-kissed life was this, with nothing to do but loaf and be bored. Here was neither peace, nor rest, nor a moments safety (London, 1903, p. 25). In Text Citations for Paraphrased Information: When taking an women's england idea from another source and placing it in your own words, it is not necessary to include the page number, but you can add it if the source is large and you want to direct readers right to the information. At the time, papyrus was used to create paper, but it was only grown and available in mass quantities in Egypt. This posed a problem for the Greeks and Romans, but they managed to have it exported to Standford Prison Essay, their civilizations. Papyrus thus remained the material of choice for women's, paper creation (Casson, 2001). How to Format In Text and Parenthetical Citations: After a direct quote or paraphrase, place in parentheses the last name of the author, add a comma, and Study then the year the source was published. Communism? If citing a direct quote, also include the Standford Prison Study, page number that the information was found on.

Close the parentheses and add a period afterwards. In APA format, if the authors name is included in the text of your project, omit their name from the in-text citation and communism and cons only include the other identifying pieces of information. Smith states that, the Museum Effect is concerned with how individuals look at a work of art, but only in the context of Prison, looking at that work along with a number of other works (2014, p. And Cons? 82). If your source has two authors, always include both names in each in-text citation. If your source has three, four, or five authors, include all names in the first in-text citation along with the date. In the Prison, following in text citations, only include the suffrage england, first authors name and follow it with et al.

1st in-text citation: (Gilley, Johnson, Witchell, 2015) 2nd and any other subsequent citations: (Gilley, et al.) If your source has six or more authors, only include the first authors name in the first citation and follow it with et al. Standford Prison? Include the year the source was published and mcdonalds sheffield the page numbers (if it is a direct quote). 1st in-text citation: (Jasper, et al., 2017) 2nd and any other subsequent citations: (Jasper, et al., 2017) If your source was written by a company, organization, government agency, or other type of group, include the groups name in full in the first in text citation. In any in text citations following it, it is Study, acceptable to shorten the group name to something that is simple and understandable. 1st citation: (American Eagle Outfitters, 2017) 2nd and delivery subsequent citations: (American Eagle, 2017)

Check out this page to learn more about parenthetical citations. Also, BibMes APA citation machine creates your parenthetical citations quickly and easily. Towards the end of creating a full reference citation, youll see the option to create a parenthetical citation in the APA format generator. The listing of all sources used in your project are found in the APA reference list, which is usually the Prison Essay, last page or part of a project. Included in this reference list are sources you used to gather research and other information. In APA format, it is not necessary to include personal communications in the reference list, such as personal emails or letters.

These specific sources only need in-text citations, which are found in the body of your project. All APA citations, or references, are listed in lion alphabetical order by the authors last name. If you have two sources by the same author, place them in Standford Study Essay order by the year of publication. Thompson, H.S. (1971). Fear and loathing in communism Las Vegas: A savage journey to the heart of the American dream . Thompson, H.S. (1998). The rum diary . If there are multiple sources with the same author AND same publication date, place them in alphabetical order by the title. Dr. Suess. (1958). Standford Essay? The cat in the hat comes back. New York, NY: Random House.

Dr. Intertextuality Examples? Suess. Prison Essay? (1958). Essay About? Yertle the turtle. New York, NY: Random House. In an APA citation, if a source does not have an author, place the source in alphabetical order by Prison Study Essay the first main word of the title. Need help creating the citations in your APA reference list?

BibMes APA formatter can help! Our APA citation machine creates your citations by entering a keyword, URL, title, or other identifying information. Need to create APA format papers? Follow these guidelines to produce a research paper in APA format: In an APA style paper, the font used throughout your document should be in Times New Roman, 12 point font size. The entire document should be double spaced, even between titles and headings. Margins should be 1 inch around the entire document and indent every new paragraph using the tab button on your keyboard. Place the pages in the following order:

Title page (An APA format title page should include a title, running head, author line, institution line, and authors note). (Page 1) Abstract page (page 2) Text or body of research paper (start on page 3) Reference List Page for tables (if necessary) Page for delivery, figures (if necessary) Appendices page (if necessary) The title page counts as page 1. Number the pages afterwards using Arabic numbers (1, 2, 3, 4). What is a running head? In an APA paper, next to the page numbers, include what is called a running head. The running head is a simplified version of the title of your paper. Place the running head in the top left corner of Standford Prison Study Essay, your project and place it in capital letters. On the title page only, include the phrase: Running head. Title page example: Running head: QUALITY LIBRARY PROGRAMS. For the mcdonalds delivery sheffield, rest of the paper or project, do not use the term, Running head. Example of subsequent pages: QUALITY LIBRARY PROGRAMS.

Microsoft Word, Google Docs, and many other word processing programs allow you to set up page numbers and a repeated running head. Use these tools to make this addition easier for Standford Prison Study Essay, you! If youre looking for an APA sample paper, check out the About You, other resources found on Standford Study, BibMe. Using BibMe to Create Citations for your Reference List or Bibliography. Looking to cite your sources quickly and mcdonalds sheffield easily? BibMes APA formatter, or APA citation generator, helps you generate your APA citations by Prison Essay entering a title, ISBN, URL, or other identifying information. Background Information and History of APA:

The American Psychological Association was founded in women's suffrage 1892 at Clark University, in Worcester, Massachusetts. APA style format was developed in 1929 by scholars from a number of different scientific fields and backgrounds. Their overall goal was to develop a standard way to document scientific writing and research. Since its inception, the APA Style Manual has been updated numerous times and Standford it is now in its 6th edition. The 6th edition was released in 2010. In 2012, APA published an intertextuality examples in books addition to their 6th edition manual, which was a guide for creating APA citations for electronic resources.

Today, there are close to 118,000 APA members. There is an annual convention, numerous databases, and journal publications. Some of their more popular resources include the database, PsycINFO, and the publications, Journal of Applied Psychology and Health Psychology. Our citation guides provide detailed information about all types of sources in MLA, APA, Chicago and Turabian styles. If required by your instructor, you can add annotations to your citations. Prison Study? Just select Add Annotation while finalizing your citation.

You can always edit a citation as well. Remember to evaluate your sources for accuracy and credibility. Questionable sources could result in a poor grade!

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Essay: Oral administration of drugs. Today various routs available for Standford the administration of Essay About drugs but the Standford Prison Study Essay oral route is the simplest and most preferable route for the administration of dosage forms. Different dosage forms are available for the administration orally. 3. Emulsion suspensions. 4. England? Solutions etc. But the problems is there in the recently invented drugs having problem with there bioavability approx. 50% of newly marketed drugs can not be given orally due to poor solubility.

The poor solubility of Standford Essay drugs can reduce the bioavability of dosage forms. Recent approaches have included the on Not administration of drug components with lipid vehicles such as oils, liposomes and self-emulsifying formulations [1, 2]. This system was not use commonly but know the days importance of lipid based drug delivery system is very height due to Essay poor water solubility of drugs. For the improving bioavability we formulate a new drug delivery system called self emulsifying drug delivery system By example, the bioavailability of Tipranavir (TPV), a nonpeptidic protease inhibitor anti-HIV drug, was doubled when dosed to suffrage england rats in a SEDDS formulation versus delivered as solid powder in a hard filled capsule [3]. developed a self-emulsifying drug delivery system for Coenzyme Q10 using polyglycolyzed glycerides as emulsifiers with a resultant 150% increase in bioavailability.4 Numerous other examples exist in the literature demonstrating enhanced bioavalibility with self emulsifying drug delivery systems 5-6 but most focus on a single formulation or small.[2] set of Standford Prison Study Essay formulations with little explanation of delivery sheffield how this formulation was developed. Standford Study? Current SEDDS formulation development, consequently, in general occurs through resource-intensive trial and error. Some mechanistic studies have been conducted exploring a range of SEDDS formulations and a specific aspect of their function, most commonly ability to mississippi masala full emulsify [7, 8]. . Improved quantitative understanding of how properties of a specific self emulsifying formulation interact with the biological environment to enable oral absorption could help optimize SEDDS formulations for enhancing bioavailability. Although a significant amount of literature exists from other fields concerning the function of emulsions [9-10], pharmaceutical formulations have not been broadly studied with respect to Prison Study Essay fundamental aspects of emulsion function, with few studies statistically developing predictive models that relate emulsion properties with formulation parameters [11]. In particular, analysis and optimization of emulsion function across a broad range of formulation parameters via experimental design has not been widely explored. One poorly understood aspect about SEDDS is the influence of different formulation components on the overall performance of these drug delivery systems in Essay on Not About You vivo.

Different types of oils with different characteristics and different surfactants combined at different ratios may influence the performance in vivo drastically. There is no guidance currently available for Prison Study formulating a drug with specific properties with self. emulsifying drug delivery formulations.12 It is mississippi movie, therefore necessary to Standford Essay investigate the influence of formulation components with a quantitative and statistically designed and analyzed manner. 3 Another knowledge in which there is a lack of understanding is the and mouse fable mechanism of how self emulsifying drug delivery systems work to enhance the overall bioavailability of a hydrophobic drug orally. Suggested mechanisms responsible of functioning of SEDDS in the GI tract environment includes the increased drug solubilization in the aqueous lumen phase due to alterations in the composition and character of colloidal environment in the GI tract fluid and increased drug absorption due to enhanced permeability permeability (e.g. widening of Study tight junctions, changes to cellular processing) and lymphatic transport [13-14-15]. Important mechanisms that would influence drug solubilization in the lumen is the rate and extent of digestion of pros and cons lipidic formulation components. Another one is the rate at which the drug is released from oil droplets especially during the Standford Prison Study process of degradation of the emulsified drug carriers by the digestive enzymes in vivo. Essay On Not About? It is essential to investigate the rate of digestion of Prison Study self emulsifying formulation lipids, rate of drug release, as well as the rate and extent of drug transport across intestinal monolayer incorporated with SEDDS in intertextuality order to understand and predict formulation functioning in GI tract. Knowledge gained from these mechanistic understandings can be used as quantitative expressions which then can be incorporated into a pharmacokinetic model that will predict oral bioavailability of Study a drug administered with self emulsifying drug delivery systems. Mississippi Full Movie? To define and understand challenges involved with oral delivery of hydrophobic drug compounds it is necessary to present a overview of Standford Study Essay current technologies.

16. Oral intake has been the most sought-after route of drug delivery by the patients as well as the manufacturers for the treatment of women's most pathological states. Despite tremendous strides made in novel non-oral drug delivery systems (DDS) till date, majority of the drug formulations available in the commercial world today are the oral ones.17 Nevertheless, oral delivery of over one-half of the Standford Prison drug compounds through gastrointestinal (GI) tract gets diminished owing to their high lipophilicity and consequently poor aqueous solubility. Oral bioavailability of such drugs, being primarily a function of their solubility and intertextuality in books, dissolution,[18-19] tends to exhibit inadequate magnitude with high intra- and inter-subject variability. Besides, oral bioavailability also depends upon a multitude of other drug factors such as stability in GI fluidsintestinal permeability, resistance to metabolism by cytochrome P450 family of enzymes present in gut enterocytes and liver hepatocytes, and interaction with efflux transporter systems like P-glycoprotein (P-gp).[20,21] explicitly illustrates the mechanisms of the physiological pathways through which the bioavailability of a drug from the conventional formulations tends to Essay get impeded. Several formulation approaches have been employed to improve the oral bioavailability of diverse drugs.

Amongst these, oral lipid-based DDS have proved their immense potential in masala full movie improving the Standford Prison poor and examples in books, inconsistent drug absorption of Standford many poorly water-soluble drugs, especially following their administration after meals.22 These include various types of lipid suspensions, solutions and emulsions.23 With applications in specific domains, the lipidic formulations, thus, have carved a singnificant niche in oral drug delivery. Self-emulsifying drug delivery systems (SEDDS) are relatively newer lipid-based technological innovations with immense promise in oral bioavailability enhancement of drugs. These formulations have shown to reduce the slow and women's england, incomplete dissolution of a drug, facilitate the formation of Prison Study its solubilized phase, increase the extent of its transportation via intestinal lymphatic system, and bypass the P-gp efflux, thereby augmenting drug absorption from the and mouse fable GI tract.24. Self emulsion having grate capacity yo increase the Essay bioavability of poorly water soluble drugs. Full? Its a isotropic mixture of oil ,surfactant, this system oil globules bind with drugs and Standford Prison Study Essay, increase the solubility of drugs. SEDDS is also known as microemulsion system. It will increase bioavability of drugs 50-100% .25-26. 1. Solid self emulsifying drug delivery system (SSEDDS) 2. Liquid self emulsifying drug delivery system (LSEDDS)

Recently day by day a new drug molequle was found but the only problems is that the bioavability of the drugs. Because oral route is the most preferable route for full the administration of drugs but poorly water soluble drugs having problems to Standford Essay formulates solid dosage form because it will reduce the bioavability of drugs.26. In the solid dosage forms numbers of examples in books excipients are use for the increasing drug solubility. They can be help in enhancing the solubility of drugs. In the SEDDS we number of excipients are use. 3. Co- surfactants. 4. Solidifying agent. They all the excipients help in the inhancing the bioavability of drugs.26. SEDDS is the isotropic mixture of oil, surfactant and co-surfactant. Thy having the capacity to Standford Prison Essay rapidely dissolve in on Not About stomach and instinal fluid and Study Essay, cover large surface area. due to this nature of SEDDS it will also use in the sustain relese drug delivery system for the instant delivery of drugs. This system can be use to sheffield increase the solubility of drugs by the help of excipients in Prison Study the oral dosage forms we can use PH modifier, water soluble organic solvents, surfactant, co-surfactants.

And oils are use long chain triglicryde and medium chain tryglyceried we also use PEG 400, propylene glycol, glycerin, non-ionic surfactants as water soluble organic solvents.36,37. 1.1 Composition of SEDDSs:- The nature of the oilsurfactant pair. The surfactant concentration. The temperature at which self-emulsification occurs. 1.1.1 Oils:- Oils can solubilize the lipophilic drug in intertextuality examples in books a specific amount. It is the most important excipient because it can facilitate self-emulsification and increase the Standford Study fraction of lipophilic drug transported via the intestinal lymphatic system, thereby increasing absorption from the GI tract . Long-chain triglyceride and medium-chain triglyceride oils with different degrees of saturation have been used in the design of SEDDSs. Modified or hydrolyzed vegetable oils have contributed widely to communism pros the success of SEDDSs owing to their formulation and physiological advantages. Novel semisynthetic medium-chain triglyceride oils have surfactant properties and are widely replacing the regular medium- chain triglyceride. 1.1.2 Surfactant:- Nonionic surfactants with high hydrophiliclipophilic balance (HLB) values are used in formulation of SEDDSs (e.g., Tween, Labrasol, Labrafac CM 10, Cremophore, etc.). The usual surfactant strength ranges between 3060% w/w of the formulation in Prison order to form a stable SEDDS.

Surfactants have a high HLB and hydrophilicity, which assists the immediate formation of o/w droplets and/or rapid spreading of the intertextuality in books formulation in the aqueous media. Surfactants are amphiphilic in Standford Study Essay nature and they can dissolve or solubilize relatively high amounts of pros and cons hydrophobic drug compounds. This can prevent precipitation of the drug within the GI lumen and for prolonged existence of drug molecules. 1.1.3 Cosolvents:- Cosolvents like diehylene glycol monoethyle ether (transcutol), propylene glycol, polyethylene glycol, polyoxyethylene, propylene carbonate, tetrahydrofurfuryl alcohol polyethylene glycol ether (Glycofurol), etc., may help to dissolve large amounts of Essay hydrophilic surfactants or the hydrophobic drug in the lipid base. These solvents sometimes play the intertextuality examples role of the cosurfactant in the microemulsion systems.27.

1.2 Microemulsions or Self-Emulsifying Drug Delivery Systems (SEDDS) Emulsions in general are thermodynamically unstable systems. The droplets of the dispersed phase are large. Microemulsions on the other hand are emulsion systems that have a droplet size of Standford Essay a few to hundreds of nanometers and are typical complex fluids that consist of three essential components: two immiscible fluids and england, a surfactant. Typically these are water-in-oil or oil-in-water microemulsions where the rheological properties of Prison Study these two liquids and microstructure of the surfactant strongly affect the resulting microemulsion . Microemulsions and micellar solutions are distinguished from emulsions by the fact that the average drop size does not grow with time, which is mississippi masala, a manifestation of thermodynamic unstability. Micellar solutions and Prison Study Essay, microemulsions on the other hand are assumed to pros and cons be thermodynamically stable. Reasons why there is tremendous attention on SEDDS include industrial trend towards the discovery and development on hydrophobic drugs and the resolution of technology transfer, stability and regulatory issues by SEDDS and Prison, the fact that they have proven pharmaceutical benefit with commercially available compounds of up to 5 fold increase in bioavailability (cyclosporine, lipid soluble vitamins, HIV protease inhibitors etc.) Self-emulsifying drug delivery systems by definition are mixtures of an oil, one or more surfactants and optionally a co-solvent or co-surfactant which when introduced into on Not About an aqueous media, under gentle agitation, forms fine oil-in-water emulsions. These systems when incorporated with a drug compound, drug is distributed in the aqueous solution entrapped inside oil droplets. SEDDS enable distribution of hydrophobic drug component in Prison Study Essay the aqueous media and creates a drug solubilization in the gastrointestinal environment. Distribution of drug inside oil droplets prevents drug from being an undisolved substance, precipitating and being excreted from About You body.

However their mechanisms of action in the body are not limited to Standford Essay solubilization enhancement and also include other processes such as intestinal permeability and lymphatic transport enhancement. SEDDS by nature are thermodynamically stable emulsions compared to pros and cons unstable regular emulsions. Their stability is thought to Standford Prison Study be dependent on their relatively small dispersed oil droplet size and narrow range of mississippi masala full movie droplet distribution. SEDDS are typically composed of emulsion droplets having a diameter of 50 nanometers to 500 nm whereas systems having droplet size less than 50 nm are called self nano emulsifying drug delivery systems (SNEDDS). For a given drug only very specific formulations will give efficient emulsification and a self-emulsifying system that will work to enhance bioavailability. Efficiency of SEDDS therefore, as explained in detail by Standford Prison Study Essay Gursoy et al., is suffrage, governed by surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge of the droplets. However, the mechanism that governs self-emulsification has not yet fully understood. It is suggested that water penetrates through the gel and Standford Prison, LC phases that occur at the surface of the intertextuality examples droplets. This is followed by Standford Prison Essay the solubilization of the water in oil phase until the solubilization limit is reached. After the limit is reached, formation of dispersion of LC phase is formed and masala full movie, this depends on the surfactant concentration. Wit this formation, SEDDS become resistant to coalescence.

Emulsion stability is governed by a variety of factors such as physical nature of the interfacial film, presence of electrostatic or steric barriers on the droplet, viscosity of the continuous phase, droplet size distribution, oil to water ratio, temperature and the amount of surfactant that is Prison Essay, absorbed on the surface of the oil droplet. The more surfactant is absorbed on the surface, the more decreased the interfacial tension between oil and water which consequently yields delayed coalescence of droplets by electrostatic and steric repulsio. Although with the addition of high amounts of drug, which is common case for potential oral dosage forms, it is harder to have stabilized emulsions. Mississippi Masala Movie? In this case, the need of using more surfactant arises that have negative aspects such as increased toxic effect of the formulation. 1.3 ADVANTAGES OF SEDDS :- More consistent drug absorption, Control of delivery profile. Reduced variability including food effects.

Enhanced oral bioavailability enabling reduction in Standford Prison dose. High drug loading efficiency. For both liquid and solid dosage forms. These dosage forms reduce the gastric irritation produced by drugs.25-26. 1.4 APLLICATION OF SEDDS : Main application of Essay About You this SEDDS to increase the bioavability by increasing the solubility of drugs. In this system we use oils for the increasing the solubility of drugs . the Standford Prison Study oils can form a layer of intertextuality examples globules on the drug so it will easily dissolve in the water.27.

1.5 Solubility and Process of Prison Study Essay Solubilization. In bioavailability of pros drug, solubility plays a key role because it is vital determinant of Standford Study Essay drug release and absorption. Any drug showed pharmacological response when it achieves desired concentration in systemic circulation and it is depending upon solubility. You? Solubility is the Prison Essay maximum amount of solute dissolved in mississippi masala movie a certain amount of solvent at a specified temperature. Essay? (Shinde A. J., 2007) 1.5.1 Process of solubilization. Factors affecting solubility.

1. Particle size. 4. Other: Nature of the solute solvent, Molecular size, Polarity, Polymorphs. Absolute bioavailability and on Not You, Relative bioavailability. Absolute bioavailability Intravenous dose is selected as a standard because the drug is administered directly into the systemic circulation (100% bioavailability) and avoids absorption step. Intramuscular dose can also be taken as a standard if the drug is poorly water soluble. An oral solution as reference standard has also been used in certain cases, but there are several drawbacks of using oral solution as a standard instead of an i.v. dose. Relative or comparative bioavailability. It is also termed as comparative bioavailability. It is denoted by Fr.

In contrast to absolute bioavailability; it is used to characterize absorption of a drug. Methods for Prison Study enhancement of bioavailability. As per definition of bioavailability, poor permeability through the biomembrane owing to inadequate partition coefficient or lipophilicity or large molecular size such as that of protein or peptide drugs are poor bioavailable drugs. Both poor solubility and permeability of drug is depends upon its physicochemical property. Biopharmaceutical Classification System (BCS) Based on intestinal permeability and women's, solubility of drugs, Amidon et al., developed Biopharmaceutical Classification System (BCS) which classify drugs into one of the Study Essay four groups. Class I: These are well absorbed orally since they have neither solubility nor permeability limitation. Class II: Shows variable absorption owing to solubility limitation. Class III: also shows variable absorption owing to intertextuality examples in books permeability limitation. Class IV: are poorly absorbed orally owing to both solubility and permeability limitation. There are three approaches in overcoming bioavailability problems are: It includes alteration of formulation, manufacturing process or physicochemical properties of Standford Study Essay drug devoid of changing chemical structure.

It includes modification of pharmacokinetic of drug by changing its chemical structure by developing new chemical entity with desirable feature or prodrug design. By enhancing drug solubility or dissolution rate: 3. Supercritical fluid recrystallization. 4. Spray freezing into liquid. 5. Evaporative precipitation into aqueous solution. 6. And Mouse Fable? Use of Standford Prison Essay surfactants. 7. Use of Essay on Not About You salt forms. 8. Standford? Use of precipitation inhibitors. 9. Alteration of pH of drug microenvironment.

10. Use of amorphous, anhydrates, solvates and metastable polymorphs. 11. Solvent deposition. 13. Selective adsorption on insoluble carriers. 14. Solid solution. 15. Eutectic mixture. 16.

Solid dispersion. 17. Intertextuality Examples? Molecular encapsulation with cyclodextrin. By enhancing drug permeability across biomembrane. 1. Standford Study Essay? Lipid technology. 3. Penetration enhancers. By enhancing drug stability. 1. Enteric coating. 3. Delivery Sheffield? Use of Prison Study metabolism inhibitors. 1.5.3 Problems and Breakthroughs of Bioavailability Enhancement Techniques. When poor wetting properties and difficulties in processing of powders are problems reduction in lion fable particle size can not applicable in such conditions. So as to avoid such problems many other techniques have been used such as solid dispersions, permeation enhancers, cyclodextrins and Prison Study Essay, nanoparticles. In fact, in some special cases, such approaches have been doing well.In the technique of reducing the size of particles, there is affinity for agglomeration of particles due to high surface charges on small discrete particles. 1.5.4 Lipid based drug delivery. Ideal properties of Lipid based formulations. 1. It should solubilize therapeutic amounts of the drug in the dosage form. 2. Essay On Not? It should maintain adequate drug solubility over the entire shelf-life of the Prison drug product (generally 2 years) under all anticipated storage conditions.

3. It should provide adequate chemical and women's, physical stability for the drug and formulation components. 4. It must be composed of approved excipients in safe amounts. 5. It should adapt to the digestive processes of the GI tract such that digestion either enhances or maintains drug solubilization. 6. Prison Study Essay? It should present the drug to the intestinal mucosal cells such that absorption into the cells and into the systemic circulation is optimized. 2.0 NEED FOR STUDY OBJECTIVE. Oral route is the most convenient and You, preferable route for the administration of Standford Study drugs but the problems is occurs due to the low solubility of lion fable drugs. Prison Study? About 50% of recently find drug molecules can not be formulate in the solid dosage form because of intertextuality examples there low solubility. The need of Standford Essay this study was to increase the solubility of poorly soluble compound. In this formulation we can formulate a self emulsifying drug delivery system with the active ingredient telmisartain. Telmisartain practically water insoluble drugs. And having poor bioavability by the help of LSEDDS we can increase solubility of telmisartain.

3. On Not About? LITRATURE SURVEY. 1. . Saritha,D. Standford Essay? et al. (2014) Prapration a stable formulation for self emulsifying drug delivery systems (SEDDS) in order to women's england enhance the solubility, release rate, and oral absorption of the poorly soluble drug, indomethacin. Based on the solubility of indomethacin in oil, surfactant and cosurfactant, pseudo-ternary phase diagrams were developed in 1:1, 1:2, 2:1, 1:3, 3:1, 4:1 ratio for SEDDS composed of labrafil, cremophor EL and transcutol P. Formulations were evaluated for drug content, phase separation, turbidimetry, zeta potential, globule size, refractive index and in vitro release. Standford Prison Study Essay? The study illustrated the potential of indomethacin SEDDS for oral administration and its biopharmaceutic performance.33. 2. Damineni,S et al (2014) developed self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to mississippi masala movie traditional oral formulations to improve bioavailability. Prison? In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively.

Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles.34. 3. Kumar,S. Women's Suffrage? et al (2014) in this article we have study upper surface of SEDDS. Standford Prison? The main advanced topic in this article is mcdonalds sheffield, solidification process of LSEDDS and the development of Study solid SE dosage the women's suffrage last find he prolems of the system and Standford Prison, solve it.35. 4. Reddy,M. et al (2014) In this article we have conclude, today huge numbers of intertextuality formulation avalables for Standford Study Essay the increasing poor water solubility of drugs , dissolution rate and bioavailability of insoluble drugs. Essay About? One of the promising techniques is SelfMicro Emulsifying Drug Delivery Systems (SMEDDS).

Liquid SEDDS were prepared using LLWL 1349, Labrafac PG as oils and cremophor EL, cremophor RH40 as surfactants and labrasol, transcutol HP as co-surfactants. Standford Prison Study? Prepared liquid SEDDS were evaluated for stability, particle size, zeta potential and percent transmittance. Selected liquid formulations were converted to solid SEDDS by adsorbing onto a solid carrier Neusilin. Prepared solid SEDDS were evaluated for communism and cons flow properties and Prison Study Essay, in-vitro drug release studies. Results proved that prepared solid SEDDS have good flow properties and communism pros, improved drug solubility and dissolution profiles (99.95%) when compared to Prison Essay pure efavirenz.36.

5. Amrutkar,C. et al (2014) The aim of the present study is to improve solubility and hence bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). self emulsifying property of various oils was evaluated with suitable surfactant and co-surfactants. Ternary phase diagram was constructed based on and mouse Rosuvastatin calcium solubility analysis for optimizing the systems. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). Prison Study Essay? The globule size of optimized system was less than 100nm which could be an acceptable nanoemulsion range. Intertextuality Examples? The average globule size of the selected F2 SNEDDS formulation (Capmul MCM [20%], Tween 20 [40%] and PEG 200 [40%]) was 88.01nm. In vitro drug release studies showed remarkable increase in dissolution of F2 SNEDDS compared to marketed formulation.37. 6. . Choudhary,S.B. et al (2014) revealed formulated and characterization solid self emulsifying drug delivery system (SSEDDS) of domperidone for filling into soft gelatine capsule.

Pseudo ternary phase diagrams were constructed and liquid SEDDS formulations were prepared which consists of oleic acid, tween 20 and propylene glycol as oil phase, surfactant and cosolvent respectively. The self emulsification properties, globule size, polydispersity index of liquid SEDDS formulations were studied upon dilution with water. The solid SEDDS was prepared by spray drying method and kneading method using Aerosil 200 as solid career. The solid state characterization of the solid SEDDS was performed by SEM, DSC, and X-ray powder diffraction. The results from this study demonstrate the potential use of SEDDS as a means of improving solubility, dissolution, and Standford Prison Essay, concomitantly the bioavailability.38. 7. .Gikwad,S. Intertextuality Examples? et al. (2012) A reaserch on Standford Essay self-emulsifying drug delivery system (SEDDS) to enhance the communism pros and cons solubility of the poorly water-soluble drug Orlistat. These drugs can be successfully formulated for oral administration, but care needs to be taken with formulation design to ensure consistent bioavailability.

Solubility of Orlistat was evaluated in various nonaqueous carriers that included oils, surfactants, and Standford, cosurfactants. Intertextuality Examples In Books? Pseudoternary phase diagrams were constructed to identify the self-microemulsification region. The self microemulsification properties, droplet size and thermodynamic stability of these formulations were studied upon dilution with water.38. 8. . Sachan,R. et al. Study? (2010) To develop a formulation For the improvement of bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations dissolution rate which may improve therapeutic performance and drug loading capacity so as to england develop alternative to Prison Essay traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively. Formulation development and screening was done based on results obtained from phase diagrams and women's, characteristics of resultant microemulsions.39. 9. Liu Y., et al., (2009) optimized and characterized an oridonin SMEDDS formulation using central composite design. In this study effect of concentration of oil andsurfactant and co-surfactant ratio has been studied. Study concluded that, this model is useful for optimization of SMEDDS formulation. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.40. 10.

Balakrishnan P., et al., (2009) prepared a solid SMEDDS of dexibuprofen by spray drying technique using Aerosil 200 as a solid carrier. After conversion in to Standford Prison Study solid form S-SMEDDS retains its self emulsification capacity. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation. In-vivo study showed that increase in bioavailability. Study concluded that, in the form of Solid SMEDDS it retains all characteristics of liquid and it can become helpful solid dosage form.41. 11. In Books? Singh A. Prison Study? K., et al., (2009) prepared and evaluated SMEDDS of Exemestane using Capryol 90, Cremophore ELP, and Transcutol P. They compared drug release with marketed formulation in different pH. They found extensive increase of drug release than marketed formulation. They also compared absorption of drug with that of drug suspension. They found enhanced drug absorption from SMEDDS.

Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.42. 12. Shaji J., et al., (2008) formulated and evaluated SMEDDS of suffrage Celecoxib. They optimized formulation using 33 factorial design. Particle size was taken as response variable. Study showed that, concentration of Standford Study different components showed prominent effect on particle size and appearance of dispersion. They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.43.

13. Atef E., et al., (2008) formulated and evaluated SMEDDS of phenytoin and compared its relative bioavailability with marketed formulation. Results showed that, extensive increase in drug release form SMEDDS as compared to that of marketed suspension. Also in-vivo study showed improvement in pros bioavailability. Standford Prison Essay? Study concluded that, SMEDDS is promising formulation to increase drug release as well as bioavailability of mcdonalds sheffield poorly water soluble compounds In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.44. 14. Fatouros D. G., et al., (2008) studied dynamic lipolysis model for absorption of drug from SMEDDS formulations. They also studied IVIVC with the Prison help of neuro-fuzzy networks.

Study concluded that, in movie evaluation of SMEDDS for prediction of in-vivo behavior in-vitro dynamic lipolysis model is a possible means.45. 15. Shikov A., et al., (2008) Prepared and characterized SMEDDS of Prison Study Essay flavonoids. Prepared SMEDDS formulation was evaluated for self emulsification capacity, droplet size and for bioavailability. Results showed that, They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and mcdonalds sheffield, hence bioavailability of poorly water soluble drug. there was 2-5 fold increase in bioavailability as compared to flavonoid in powder form.46. 16.

Woo J. S., et al., (2008) developed SMEDDS of Itraconazole and Standford Prison Essay, studied and compared in-vivo study in human volunteers with marketed formulation having double dose. Study concluded that, there is extensive increase in bioavailability with reduced food effect by SMEDDS formulation as compared with marketed formulation. They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.47. 17. Mandawgade S. D., et al., (2008) developed SMEDDS using natural lipophile as oil phase and also compared its performance with synthetic oils. For this study beta-Artemether was used as drug.

Oil was previously evaluated for toxicity studies. Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. Study concluded that, performance of natural lipophiles is better than that of sheffield commercially available synthetic oils hence can be used in SMEDDS as it is safe.48. 18. Yi T., et al., (2008) developed a controlled release solid SMEDDS of nimodipine using HPMC. They have prepared batches by mixing drug with HPMC and another batch by dissolving drug and HPMC in the SMEDDS. Prepared self emulsifying formulations were evaluated for surface characterization, reconstituted properties, inner physical structure and in-vitro drug release study. Study concluded that, It can be possible to Standford Prison Essay formulate controlled release formulations of poorly water soluble drug by SMEDDS using high viscosity grade HPMC.49. 19.

Yi T., et al., (2008) developed a S-SMEDDS of nimodipine. And Mouse? Prepared S-SMEDDS was evaluated for in-vitro and Prison, in-vivo absorption study. Communism Pros? They have studied effect of dilution media and enzymatic digestion on solubilization of drug .Results showed that, there is faster dissolution rate of drug from S-SMEDDS than that of conventional tablet and Standford Prison Study Essay, enhancement of absorption as compared to liquid SMEDDS. . Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. Study concluded that, performance of natural lipophiles is better than that of commercially available synthetic oils hence can be used in SMEDDS as it is safe. Study concluded that, S-SMEDDS can become constructive dosage form for oral use.50. 20. Abdalla A., et al., (2008) Study concluded that, S-SMEDDS can become constructive dosage form for oral use. developed self emulsifying formulation in the form of pellets by women's suffrage england extrusion and spheronization technique. In. this study they found that, droplet size decreases after dilution. Study concluded that, solubilzation depend on concentration of Standford Study secretions like bile salts and fable, phospolipid.

SMEDDS can besuccessfully transformed into Study Essay pellets form and can become another method to encapsulate material into hard gelatin capsule.51. 21. Lu J. L., et al., (2008) developed SMEDDS of communism pros 9NC to enhance bioavailability and anticancer effect. They prepared microemulsion of 9NC and characterized for citotoxicity and bioavailability study. Essay? Bioavailablity and anticancer effect have been compared with suspension of 9NC. Study concluded that, antitumor activity has been enhanced in the form of SMEDDS.52. 22. Patel D., et al., (2007) developed SMEDDS of Acyclovir. Prepared formulations were evaluated for different parameters.

Absorption of drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in intertextuality bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach. . Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. Essay? Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.53. 23.

Cirri M., et al., (2007), formulated oral liquid spray formulation of xibornol using SMEDDS. Prepared formulations were evaluated for rheological, stability, SAXS and mcdonalds sheffield, in-vivo study. Standford Essay? The study found that, SMEDDS can be used to intertextuality examples in books prepare stable and effective oral liquid spray formulation. Absorption of drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach.54.

24. Essay? Patil P., et al., (2007) formulated a SEDDS for simvastatin. Prepared SEDDS was evaluated for turbidometric analysis, particle size, in-vitro drug diffusion and in-vivo study in rat. Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of lion fable drug suspension. Study concluded that, there was better biopharmaceutical performance of Standford Prison Study Essay drug from mcdonalds delivery SEDDS.55. 25. Patel A. Prison Study? R., et al., (2007) formulated and evaluated SMEDDS of fenofibrate. Lion And Mouse Fable? From solubility study of Standford Essay drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. Women's England? From this SMEDDS were prepared and evaluated for thermodynamic, dissolution, stability study and lipid lowering capacity. Standford Prison Essay? Study concluded that, SMEDDS can improve dissolution rate and hence bioavailability of drug which become substitute for oral drug delivery system. Women's? Study concluded that, there was better biopharmaceutical performance of Standford Study Essay drug from SEDDS.56.

26. Lion Fable? Shen H., et al., (2006) prepared and evaluated SMEDDS of atorvastatin using Labrafil, PEG and Cremophor RH40. From solubility study of drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. SMEDDS capsule of atorvastatin were prepared and drug release were studied and compared with conventional tablet. Results showed that release of drug was much higher from Prison Study Essay SMEDDS capsule than that of tablet. Study concluded that, bioavailability of drug can be enhanced using SMEDDS capsule than conventional tablet. Examples In Books? controlled release of drug can be obtained from lipid formulations in tablet dosage form.57.

27. Boonme P., et al., (2006) characterized colloidal state in microemulsion system. They constructed pseudo ternary phase diagram by water titration method. different process parameters affect dissolution rate of drug from tablet. Study concluded that, controlled release of Standford Study Essay drug can be obtained from lipid formulations in tablet dosage form. Different samples were prepared by keeping surfactant concentration of 45 % and by varying proportion of water.

Prepared samples were evaluated for appearance, viscosity, conductivity, DSC, SEM and NMR. Study concluded that, if composition has 15 % of water, it contain reverse micelles, W/O emulsion obtain if it contain 15-30 % of water and mcdonalds, it gives O/W emulsion of it contain more than 35 % of Study Essay water.58 28. Nazzal S., et al., (2006) evaluated different process parameters which affect release of drug from SNEDDS in tablet dosage form. Solid preparation was prepared to study absorption of drug in rat and dog. Prepared tablets were evaluated for dissolution and stability studies. Results showed that, different process parameters affect dissolution rate of women's suffrage drug from tablet. Study concluded that, controlled release of drug can be obtained from Prison Study Essay lipid formulations in tablet dosage form.59 29.

Wu W., et al., (2006) prepared SMEDDS of silymarin. From solubility study of drug Tween 80, ethyl alcohol and ethyl linoleate were selected as formulation components Solid preparation was prepared to study absorption of masala full drug in rat and dog. Prison Study Essay? Results showedthat Florite RE gives more absorption of drug both in rat and dog. Results showed that, there is increase in particle size as increase in drug loading in formulation. Drug release was much higher than that of crude drug powder. Study concluded that by women's england using SMEDDS bioavailability of Prison Study silymarin can be enhanced.60 30.

Ito Y., et al., (2005) prepared solid formulation of gentamicin using different adsorbents and surfactant to enhance absorption of drug. Florite RE, Neusilin US2 and Sylysia 320 were used as adsorbents and Labrasol was used as surfactant. Prepared formulation was evaluated for particle size, drug release and bioavailability study. Results showed that, there is increase in particle size as increase in delivery drug loading in formulation Study concluded that by using adsorbent and surfactant system oral solid formulations can be prepared so as to increase absorption of poorly absorbable drug.61 31. Sha X., et al., (2005) studied effect of charge and Prison Study, dilution on women's england TEER and permeability of Study Essay mannitol by formulating SMEDDS using Labrasol and also studied effect of dilution of mcdonalds delivery sheffield surfactant on ZO-1 and F-actin. Study concluded that, SMEDDS of Standford Prison Study both positive and mcdonalds delivery, negative charge containing Labrasol are capable of Standford Study enhancing the paracellular tramsport of mannitol across Caco-2 cell at different dilutions. , there was significant increase in rate and examples in books, extent of absorption of drug as compared to Prison capsule. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Essay About You? Study concluded that, SMEDDS can be beneficial for Standford Prison Essay oral delivery of poorly water soluble drug such as simvastatin.62 32. . Subramanian N., et al., (2004) developed and mississippi masala full, optimized SMEDDS of Study Celecoxib using simplex lattice mixture design. In Books? Prepared SMEDDS were evaluated for Prison Essay Clarity, solubility, in-vitro dissolution and in-vivo study. Results showed thatRelative bioavailability with capsule was found to be 132 %. Study concluded that, prepared formulation will reduce variability in absorption and rate and gives rapid onset of action of drug.

It was also found that, there was 1.5 fold increases in suffrage bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.63 33. Kang B. Standford Prison? K., et al., (2004) prepared SMEDDS of simvastatin using Carpryol 90, Cremophor EL and communism pros, Carbitol. Prepared formulations were evaluated for Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of Prison Study Essay drug, in-vitro dissolution study and bioavailability study. Fable? Results showed that, in-vitro of Standford Study drug was much higher that that of delivery conventional tablet. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.64 34. Patil P., et al., (2004) formulated a gelled SEDDS of ketoprofen using Captex 200, Tween 80 and Standford Study Essay, Capmul MCM.

Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug. Study concluded that, as concentration of gelling agent increases it increase droplet size of emulsion formed which helps in slowing drug diffusion. It was also found that, as concentration of Essay on Not About You co-surfactant increase drug release from dosage form also increases.65 35. Holm R., et al., (2003) importance of this examined oral absorption and lymphatic transport of halofantrine in SMEDDS containing triglycerides, Sustained drug release was achieved by Standford Essay using Silicon dioxide as gelling agent which retarded release of drug. Maisine-35-1 and Cremophor EL. Study verified that, after administration of halofantrine in SMEDDS lymphatic transport and absorption was affected. Study concluded that, by Essay About You using differentstructure of triglycerides it is achievable to enhance lymphatic transport of compound without affecting its availability.66 36. Itoh K., et al., (2002) the aim of Standford Study Essay this present researched topic improved solubility of N-4472 by formulating self-micro emulsifying system using Gelucirei??i?? 44/14, HCO and SDS. Pros? Study concluded that, formulate sedds to enhance the bioavability and formed stable microemulsion droplets. SDS showed vital role in stability of microemulsion droplets.67 37.

Agarwal V., et al., (2000) investigated effect griseofulvin SMEDDS addition to silica and silicate on flow properties and in-vitro drug release. Results showed that, increase in surface area increases dissolution of drug. Study concluded that, nature and amount of adsorbent affect flow properties and Prison Study Essay, dissolution of drug in SMEDDS. In-vitro drug release showed that, there was increase in pros and cons drug release as compared to powder formulation.68 38. Kim H. J., et al., (2000) developed SMEDDS of Study idebenone using Labrafil 2609, Labrasol. Transcutol and Plurol oleique WL1173 so as to enhance bioavailability by pros and cons the increasing the solubility of the poorly water solublr drug. Results showed that, in-vitro dissolution rate of drug were increased 2 folds than that of tablet. Study concluded that, SMEDDS can be used as substitute for traditional oral formulations to enhance bioavailability of Prison Study Essay idebenone.69 39. Chen G. L., et al., (1996) the importance of this present researched study was validated bioanalytical method for determination of Verapamil from plasma by HPLC for pharmacokinetic study of Verapamil. They also studied sensitivity, specificity, linearity, accuracy, precision and women's suffrage england, sample stability of method. For the purpose of sedds evaluation.70 40.

Shah N. H., et al., (1994) the aim of this study was investigated emulsification efficiency of polyglycolyzed glycerides (PGG) and Standford Study Essay, polyethylene glycol (PEG). Women's Suffrage England? They prepared SEDDS using different concentrations of PGG as emulsifiers,oils and different type of surfactant and co-surfactant. Neobee M5 and Prison Study, Peanut Oil were selected as oil. Drug having good solubility in and cons oil was selected for this study. Study showed that, PGG can be used as emulsifier for preparation of SEDDS.71 MATERIAL METHOD 4. MATERIAL AND METHOD 4.1 MATERIALS Table 4.1: List of materials with sources S. No. Materials Source 1. Prison? Telmisartan Skymap Pharmaceuticals, Roorie 2. Tween 80 Loba chemic laboratory regents Mumbai 3. PEG 400 Nasco laboratory 4. Methanol Loba chemic laboratory regents Mumbai 5. Hydrochloric acid Loba chemic laboratory regents Mumbai 6. Orange oil Burgone laboratory Mumbai Table 4.2: List of suffrage england equipments with make S. No. Equipment Make 1. Analytical balance Fuji electronic balance 2. Melting point apparatus Jyoti digital auto melting apparatus 3. Standford? UV Spectrophotometer Jasco japan-v630 4. Dissolution apparatus Jyoti standard dissolution apparatus 5. On Not You? FTIR Jasco-japan FT/IR/4100 7. mixing Jyoti lab gwl. INDIA 8. Hot air oven Jyoti lab gwl.

INDIA 9. Water bath Jyoti lab gwl.INDIA 4.1.1 Drug profile: Telmisartan72 Telmisartan is 4-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Structural formula Figure 3.1: Structure of telmisartan Molecular formula- C33H30N4O2 Molecular weight- 514.6 Definition 4-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Standford Prison? Content: 99.0 per cent to 101.0 per cent (dried substance). Category: Antihypertensive. Dose: 20 to 80 mg. Half life: 24 hrs. Appearance: White or slightly yellowish, crystalline powder. Mcdonalds Sheffield? Solubility: Practically insoluble in water, slightly soluble in Standford Prison Study Essay methanol, sparingly soluble in methylene chloride.

It dissolves in 1 M sodium hydroxide. It exhibits polymorphism. Melting point: 261 263oC. Storage: it should be stored at room temperature (15 30 i??i??C), away from moisture and light. Lion Fable? Mechanism of action: It is an angiotensin II receptor antagonist. Telmisartan exhibits high affinity with the angiotensin II type one receptors in adrenal gland and in vascular smooth muscles. It works by binding to the angiotensin II receptor. It inhibits the action of angiotensin which is a vasoconstrictor.

Angiotensin also stimulates the synthesis and release of aldosterone. Prison Study? By blocking the on Not You vasoconstrictor effect of the angiotensin and blocking the aldosterone, Telmisartan reduces the systemic vascular resistance. Pharmacokinetics: Absorption: After the oral administration peak concentrations (Cmax) of telmisartan are attained in 0.5 to Study 1 hour. Ingestion with food slightly decreases the bioavailability of Telmisartan. Absolute bioavailability is dose dependent. At 40 and 160 mg the bioavailability was found to and cons be 42% and 58%, respectively. Prison Study Essay? Distribution: Binding with plasma proteins is delivery, constant with the recommend doses. It is highly binding with the plasma proteins (more than 99.5 %).

It has a volume of distribution of Prison Study Essay around 500 L. Metabolism: Telmisartan is metabolized by forming a pharmacologically inactive compound acyl glucuronide by conjugation. The only identifiable compound in the human plasma and urine is the glucuronide. Elimination: Telmisartan has a half life of 24 hour and total plasma clearance of more than 800 mL/min. More than 97% of the orally/IV administered telmisartan is eliminated in the feces via biliary excretion, unchanged. Uses: It is used to treat high blood pressure (hypertension). Delivery Sheffield? Adverse effects: The common reported adverse effects of telmisartan are upper respiratory tract infection (URTI) (7%), Back pain (3%), Diarrhea (3%), Myalgia (3%), and Study, Sinusitis (3%).

Some rare adverse effects (1%) are abnormal ECG, anemia, angina, angioedema, bradycardia, eczema, epistaxis, gout, and hypercholesterolemia. Drug interactions: Telmisartan has found interacting with several drugs such as, benazepril, benazepril, benazepril, benazepril, benazepril, and benazepril etc. Caution is advised when combination will be used. Dosage forms: It is commonly used in the form of tablets of 20, 40, and 80 mg. 4.1.2 TWEEN 80 72-73 Chemical Name: Tween 80 Molecular Formula: C24H44O6 Formula Weight: 428.600006103516 Tween 80 Property Boiling point- 100i??i??C. Dencity 1.08 g/mL at 20 i??i??C. Vapour pressure- 230 i??i??F. storage temp. : Store at RT. From- viscous liquid. Water Solubility : 5-10 g/100 mL at and mouse fable 23 i??i??C. EPA Substance Registry System: Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.(9005-65-6)

Tween 80 Chemical Properties,Usage,Production. Yellow to amber liquid. Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste. Air Water Reactions.

Tween 80 is incompatible with strong alkalis and oxidizers. Tween 80 is probably combustible. 4.1.3 ORANGE OIL 72-73:- It was the important and essincial oil can be produse by the cells in the fruits of oranges. They can also be extracted by orange juse it will compose mostely d-limonene. That will be extract to the oil by Standford Study distillation. Odour- fresh and tangy smell, Coloue- yellow to and cons orange in color. Self life- approximately 6 months.

Origin of Sweet orange oil. This evergreen tree has dark green leaves and Study, white flowers and bright orange round fruit with roughish skin. The trees are native to China, but are now cultivated extensively in America. 1. It can be used many Curacao type liqueurs. 2. for the flavoring of food. 3. drink and confectionery. 4. when added to furniture polish. 5. helps to suffrage england protect against damage from insects. The orange oil are extracted by cold-pressing and yields 0.3 -0.5 %. It can also use for the medicinal perpose that will gives several therapeutic actions are antiseptic, anti-depressant, antispasmodic, anti-inflammatory, carminative, diuretic, cholagogue, sedative and tonic. The main chemical components of Standford Prison orange oil are a-pinene, sabinene, myrcene, limonene, linalool, citronellal, neral and geranial.

1. It is a safe non-toxic, non-irritant and non-sensitizing oil, 2. yet care must be taken with it since it can have a phototoxic effect. 3. It should therefore preferably not be applied before going out into sunlight for prolonged periods. Iupac name polyethylene glycol. 90.0 cst at 25 i??i??C, 7.3 cst at 99 i??i??C.

PEG 400 properties. 1. (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. 2. It is communism and cons, a clear, 4. viscous liquid. 5. Due in Prison Study part to mcdonalds delivery sheffield its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations. 1. PEG 400 is soluble in Study water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

2. PEG 400 is strongly hydrophilic. 3. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log ), indicating that when PEG 400 is mixed with water and hexane, 4. there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1] PEG 400 is soluble in delivery water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons. 4.2 Preformulation studies 72,73,74,75. To develop a safe, stable and therapeutically effective dosage form, preformulation studies are necessary to perform. The preformulation studies, which were performed in this project, include identification of drug, melting point analysis, solubility analysis, and Standford Study Essay, quantitative estimation of drug.

4.2.1 Identification tests. Physical appearance: The drug was white, odorless crystalline powder. Melting point analysis: Melting point of telmisartan was determined by and cons capillary method using melting point apparatus (Rolex- Digital melting point apparatus). FTIR study: Drug sample was vacuum dried for 12 h before IR studies. IR spectra of pure telmisartan, PEG 4000, mannitol and solid dispersions of telmisartan were obtained by Standford Study a Shimadzu IR Prestige-21 FT-IR spectrophotometer using KBr pellets. The scanning range used was 4000 to 400cm-1.

The observed peaks were reported for functional groups. 4.2.2 Loss on drying73-74. It was determined on 1 g drug by drying it in a hot air oven at 105oC. The weight was determined at 15 min intervals till the difference was not more than 0.5 mg. The total difference in lion fable weight should not be more than 0.5%. 4.2.3 Determination of max 73. Accurately weighed sample of 10 mg of Standford Prison Essay telmisartan was dissolved in 50 mL of mississippi masala full methanol in a 100 mL volumetric flask and then the volume was made up to 100 mL with methanol.

Then, 1 mL of Standford Essay this stock solution was pipetted into on Not About a 10 mL volumetric flask and volume was made up to the 10 mL mark with methanol. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). The same procedure was followed to determine the max in HCl buffer (pH 1.2). The prepared solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu). To determine max in water, accurately weighed 10 mg sample of telmisartan was dissolved in 50 mL of methanol in a 100 mL volumetric flask and volume was made up to 100 mL with methanol. Then, 1 mL of this stock solution was pipetted into a 10 mL volumetric flask and volume made up to the 10 mL mark with distilled water. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). 4.2.4 Quantitative estimation of drug73-74. Drug was estimated in the range of 3-15 mcg/mL for telmisartan in water (pH 7.0), HCl buffer (pH 1.2) and methanol.

Preparation of Standford Prison Study HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and lion, volume was adjusted to 200 mL with distilled water32. 4.2.5 Construction of calibration curve of Study telmisarta73. Preparation of calibration curve in methanol: The 25mg of accurately weighed telmisartan was dissolved in 25 mL of methanol to give standard solution (1000 i??i??g/mL). Intertextuality Examples? From this standard solution, 3 mL was pipetted out and volume was made up to 100 mL with methanol referred as stock solution of concentration 30i??i??g/ mL. Aliquots of 1 mL, 2 mL, 3 mL, 4 mL and 5 mL of stock solution were pipetted out into separate 10 mL volumetric flask. The volume was made up to the mark with methanol.

This results in samples of 3, 6, 9, 12 and 15 g/mL concentration, respectively. The absorbance of prepared solution of Standford Study telmisartan in methanol was measured at 296.5 nm in pros and cons Shimadzu UV-1700 spectrophotometer against an appropriate blank. Preparation of calibration curve in HCl buffer (pH 1.2): Exact procedure was followed as described above by using HCl buffer (pH 1.2) instead of methanol. The absorbance was recorded at Study 296 nm. 4.2.6. solublity of telmisartain in different medium. Solubility of telmisartain was determine in the different medium by heand shaking method. 3.3 Formulation 76. 4.3.1 identification of microemulsion region : Determine solubility of telmisartain in lion fable different -2 medium then select three medium orange oil as oil, PEG 400 as surfactant and tween 80 as co-surfactant. Micro-emulsion region was identify by constructing pseudo ternary phase diagram with the help of different proportion of surfactant and Standford Prison Study, co-surfactant (1:1, 2:1, 3:1). They are mix with oils at different proportion (1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, 9:1) and the complete mixture was titrate with water and mcdonalds, noted the equbliurem point.

At which point the mixture will show clear. 4.3.2 preparation of liquid SMEDDS: Due to the higher microemulsion region in Standford Study Essay the 3:1 proportion (surfactant:co-surfctant) was selected for women's suffrage england the preparation of LSEDDS. 1. Required amount of PEG 400 and Standford Study, tween 80 was take and mix with the help of stirrer until they compatibly mix. 2. Lion Fable? Aquaretly weight telmisartain and take required amount of orange oil and mix il. 3. Drug mixture place on water bath until drug completely dissolve in oil. 4. Both the mixture are mix togather on the magnatic stirrer untill they are compleately mix and form a isotropic mixture. 5. Store in the glass bottle.

Table 4.3 chemical requirements. Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg. 4.4 CHARACTERIZATION :76-77. 4.4.1 stability study :76. heating cooling cycle: for the stability study of LSEDDS pass six cycle between hot and cool temperature (40c-450c) with storing not less then 48hrs at each temp. not seen any type of phase sapration. centrifugation test: After passing heating cooling cycle it would be pass with centrifugation test. The sample of Standford Prison Study Essay LSEDDS placed in centrifuge for 30min and show any type of precipitation. If not seen it would be go to the next stability test. freeze thaw cycle: This test is again at cool and hot temperature (-210C to pros and cons +250C) 48 hrs at each temp. If the LSEDDS pass all the stability parameter means the Standford Study Essay system becomes stable. 4.4.2 cloud point measurement : 76-77. Liquid SMEDDS was diluted with distilled water at 250 times LSEDDS : distill water(1:250), placed in a water bath and its temperature was increased slowely-2.

Cloud point was measured as the temperature at which there was a sudden appearance of cloudiness visually. 4.4.3 solubility test .77-78. Solubility of pros LSEDDS was determine at Prison Study Essay buffer solution at 1.2ph, 7.4ph, and methanol by using standard paddle type dissolution test apparatus. Preparation of HCl buffer (pH 1.2): 50 mL of pros and cons 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and Prison, volume was adjusted to and cons 200 mL with distilled water. Buffer pH 7.4: Mix 50 mI of Standford solution containing 1.944 per intertextuality cent w/v ofsodium acetate and 2.946 per cent w/v of barbitone sodium with 50.5 mI of 0.1 M hydrochloric acid, add 20 mI of an Prison Study 8.5 per cent w/v solution of sodium chloride and in books, dilute with water to 250 mI.

4.4.4 efficiency of self emulsification :76-77. Using USP- type-II dissolution test apparatus (Veego VDA-8DR). 1 mL of Liquid SMEDDS was added drop wise to Prison Essay 200 ml of 0.1 N HCl at 37i??i??C. agitate using by examples using standard stainless at rotating paddle at 60 rpm. SMEDDS assessed visually according to the rate of emulsification and final appearance of the emulsion. 4.4.5 Robustness to dilution :76. it can be studied by by diluting LSEDDS at different concentration with distill wate. 1. Prepare HCL buffer solution PH 7.4, PH 1.2. 2. Prepare dilution with both the solution at Study following concentration. 3. Store for 12 hrs.

4. Sheffield? Observe any type of Standford Study Essay phase saperation or pracipation. 4.4.6 % transmittance :76. For the determination of % transmittance take. 1. 1ml of LSEDDS and diluted till 100ml with distilled water. 2. Scan this sample in the uv spectroscopy. 3. observe any type of turbidity and % transmittance. 4.4.7 Dye solubility test : 76. This test can be perform for the conformation of oil in water nature of lion and mouse fable LSEDDS by observing sopntenious dispersion. 1. Take water soluble dye and Standford, sufficient quantity of LSEDDS. 2. Rapidly incorporate dye into the system. 4.4.8. in vitro drug release:76-77.

In vitro dissolution study of LSEDDS using type -2 dissolution test apparatus in england buffer solution ph 1.2, ph 7.4 at 370 c. Drug release in buffer solution at Study Essay 1.2 PH :- 1. Lion And Mouse? Prepare buffer solution 1.2 PH by the help of indian pharmacopeia. 2. Fill in the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in the apparatus. Start the assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min. 5. The all sample was filtered with whatmant filter paper.

And dilute upto 10ml. 6. Standford Prison? If there concentration is high then take again 1ml to all the samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. Drug release in buffer solution at 7.4 PH :- 1. Prepare buffer solution 7.4 PH by the help of indian pharmacopeia. 2. Fill in the type-2 dissolution test apparatus upto 900ml . 3. Mcdonalds Delivery Sheffield? Palce 2ml sapmle of LSEDDS in the apparatus. Start the assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min.

5. Study Essay? The all sample was filtered with whatmant filter paper. And dilute upto 10ml. 6. If there concentration is high then take again 1ml to all the samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. 4.4.9 drug contant:76-77-78-79. drug content of LSEDDS should be determine by diluting 1 ml sample of LSEDDS with distill water.

Take there absorbance in uv-spectroscopy at296nm. 1. Take 1ml sample of LSEDDS and dilute with distill water upto 100ml. 2. If the concentration of masala full sample was high then furthers 1ml sample dilute with distill water upto 10ml. 3. Scan this sample in uv-spactroscopy. 4. Calculate there percentage by the help of leaner line equation. RESULT AND DISCUSSION. Table 5.1: Melting point of telmisartan.

S. No. Melting point Result. 5.1 LOSS ON DRYING: The results were within the acceptable limit which is 0.5%. Table 5.2: Loss on drying. S.No. Time (min) Weight (mg) Difference in Prison Essay weight (mg)

Total difference 2.9. 5.2 FTIR spectroscopy: FT-IR spectra of pure drug telmisartan and communism pros and cons, its solid dispersion which are shown in figure 7.1 and 7.4. Standford Study? There was not any significant interaction found between drug and carriers which confirms the stability of drug in the formulation. Table 5.3: Major peaks observed in FTIR spectrum of intertextuality in books telmisartan. S. No.

Standard peak Observed peak Comments. 1. 3059.1cm-1 3080 cm-1 C-H stretching (aromatic) 2. 2958.8-2868.15 cm-1 2870-2738.92 cm-1 C-H stretching (aliphatic) 3. 1697.36 cm-1 1687.71 cm-1 C=O stretching. 5. 1521.84-1458.18 cm-1 1462.04 C=C stretching ring. Figure 5.1: FT-IR spectra of pure telmisartan.

5.4 LEMDA MAX OF TELMISARTAIN IN DIFFERENT SOLVENT SYSTEM : Table 5.4: Solvent systems, their parameters and values. S.No. Solvent system Parameters Values. 1. Methanol i??i??max 296.5 nm. Beers law range 3 15 mcg/mL. Regression line equation y = 0.050x + 0.007. Regression coefficient (R2) 0.999. 2. Buffer 7.4 i??i??max 298 nm. Beers law range 3 15 mcg/mL. Regression line equation y = 0.043x + 0.004.

Regression coefficient (R2) 0.999. 3. HCl buffer (pH 1.2) i??i??max 296 nm. Beers law range 3 15 mcg/mL. Regression line equation y = 0.046x + 0.007. Regression coefficient (R2) 0.999. 5.5 CALIBRATION CURVE OF TELMISARTAN IN DIFFERENT SOLVENT SYSTEM. Table 5.5: Calibration curve of telmisartan in HCl buffer pH 7.4 and Standford Prison Study Essay, HCl buffer pH 1.2 at max 298 nm and on Not, 296 respectively. S.No. Concentration (i??i??g/mL) HCl buffer pH 7.4 HCl buffer pH 1.2. Absorbance Regressed Absorbance Absorbance Regressed Absorbance.

2. 3 0.139 0.133 0.153 0.145. 3. 6 0.270 0.262 0.294 0.283. 4. 9 0.401 0.391 0.423 0.421. 5. Standford Prison Study Essay? 12 0.537 0.520 0.567 0.559. 6. 15 0.657 0.649 0.706 0.697. S.No.

Concentration (i??i??g/mL) Methanol. Absorbance Regressed Absorbance. Table 5.6: Calibration curve of telmisartan in communism pros and cons methanol at max 296.5 nm. Figure 5.2: Calibration curve of Prison Study Essay telmisartan in intertextuality examples buffer 7.4 ph at 298 nm. Figure 5.3: Calibration curve of telmisartan in HCl buffer pH 1.2 at 296 nm. Figure 5.4: Calibration curve of telmisartan in methanol at Standford Prison Essay 296.5 nm.

5.6 SOLUBILITY OF TELMISARTAIN : Table 5.7: solubility of telmisartain in different medium. S.NO. MEDIUM SOLUBILITY. 1. Water Insoluble. 2. Mississippi Masala Movie? Hcl Springly soluble. 3. Methanol soluble. 5. PEG400 Soluble. 6. Tween 80 Springly soluble.

7. Tween 20 Springly soluble. 8. Span 80 Springly soluble. 5.7 IDENTIFICATION OF MICRO-EMULSION REGION BY PREPAPE PSUDO TERATORY PHASE DIGRAM. In this formulation preportion of surfactant and co surfactant is 1:1. Table 5.8: identification of micro-emulsion region. SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is 2:1. Table 5.9: identification of micro-emulsion region.

SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is 3:1. Table 5.10: identification of micro-emulsion region. Smix : OIL END POINT. Result- Best micromulsion was found to be In formulation 3 at 5:5 proportion of oil and mixture of surfactant and co-surfactant denoted as smi. 5.8 FORMULATION OF LIQUID-SELF EMULSIFYING DRUG DELIVERY SYSTEM (LSEDDS). 5.8.1 chemical requirement: Table 5.11: chemicals requirements . Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg/2gm. 5.9 EVALUATION OF LSEDDS.

5.9.1 stability study. Physical stability was important parameter in the emulsion system it can be affected the performance of the system, it can be occurs due to Standford the precipitation of drug. Due to the poor stability of women's system bioavability of drug also affected. For the Standford Study Essay thermodynamic stability study of LSEDDS was perform by following perameater. 1. Heating cooling cycle.

2. Centrifugation test. 3. Freeze thaw cycle. When system can not show any type of examples in books phase separation during heating cooling cycle then syatem can be tested in the centrifugation for the drug pricipation then apply freeze thaw cycle for Standford Prison Study Essay the stress test. heating cooling cycle : 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation.

450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. Table 5.12: six cycle of heating cooling temp. Result not seen any type of phase saperation. Centrifugation test:

Result- LSEDDS was centrifuge for communism 30 min there was not seen any type of precipitation and Standford Prison, phase saperation. freeze thaw cycle. Table 5.13: three cycle of -210c to +250c. Cool temp. No change.

Hot temp. No change. Cool temp. No change. Hot temp. No change. Cool temp. Suffrage? No change. Hot temp. No change. 5.9.2 cloud point measurement. Table 5.14: Cloud point. Sample Cloud point.

Result- cloud point of this emulsion system was found to be more then 860c. which indicates that our LSEDDS was stable at the physiological temperature without any risk of phase separation. 5.9.3 solubility study: Table 5.15: solubility of LSEDDS. Medium Solubility time. Buffer solution PH 1.2 Less than 5min. Buffer solution PH Less than 5min. 0.1 N HCL Less than 5min.

Result solubility of this system was found to Prison Essay be less than 5min which indicates that the formulation also use in lion the sustain release drug delivery system with maximum bioavability. 5.9.4 Efficiency of self-emulsification. Sample Efficiency of Prison Study Essay LSEDDS. 1 Less than 1min. 2 Less than 1min. 3 Less than 1min. Result this system rapidly form micro emulsion with in 1min it was clear and appearance was slightly blush. 5.9.5 Robustness to communism dilution : Table 5.15: dilution with different solvents. Concentration Water Buffer solution.

PH 1.2 Buffer solution. 50 times No change No change No change. 100 times No change No change No change. 500 times No change No change No change. 1000 times No change No change No change. Result in Prison Study the robustness dilution not seen any type of phase separation and pracipation. Result- % trasmittance of this system was found to be 93.5. 5.9.7. dye solubility test.

Result- type of movie emulsion was conform by using dye solubility test in Standford Study Essay which a water soluble colourfull dye rapid incorporate in the LSEDDS and women's, observe. Which indicates that the continuous phase in this system is water. so it was conform that the LSEDDS was o/w micro emulsion. 5.9.8 in-vitro drug release profile. drug release in buffer solution PH1.2. Table 5.16 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 7.35 42.43. 15 min 11.63 61.36. 30 min 1.83 75.45.

45 min 18.64 83.33. 60 min 23.31 89.02. 90 min 27.15 95.26. 120 min 29.48 95.56. Figure 7.4 commulative % drug release of SEDDS and plain telmisartain in PH 1.2. drug release in buffer solution PH 7.4.

Table 5.17 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 11.38 47.39. 15 min 14.92 54.43. 30 min 19.61 73.13. 45 min 24.48 81.68. 60 min 28.29 90.83. 90 min 32.62 96.54. 120 min 33.46 98.12.

Figure 7.6 % commulative drug release of Standford LSEDDS and plan telmisartain in PH 7.4. 5.9.9 drug content estimation. Table 5.18 drug content: The oral route is the most preferred method of delivery administration of drugs. Unfortunately, this route is Study Essay, not possible for 50% of lion currently marketed drug compounds due to their low solubility in water and low oral bioavailability. We study that self-emulsifying drug delivery system (SEDDS) can be used for the improvement of bioavailability of the drug. In the preparation of this system containing with telmisartain as active pharmaceutical ingredient. To increase bioavailability solubility of this drug. Due to Standford Study Essay poor solubility of women's suffrage telmisartain it cannot be formulate in the oral drug delivery system. But with the help of Standford Prison LSEDDS its possible to mississippi masala movie give telmisartain via oral drug delivery system.

After the complete study of LSEDDS we conclude that the system was very useful for the active drug molecules having poor solubility. 1. Yamamoto, J. and H. Tanaka, prepare neomatic phase in the liquid micro-emulsion. Nature (London), 2001. 409(6818): p. 321-325. 2. Porter, C.J.H., N.L. Trevaskis, and Standford Study Essay, W.N. Charman, Lipids and lipid-based formulations: for the optimization of delivery drug delivery by oral route lipophilic drug. Nature Reviews Drug Discovery, 2007. 6(3): p. 231-248.

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SBT Gattefosse 1994; 87: 4954. 33. Saritha D, Penjuri SCB, Nagaraju R. Formulation and evaluation of mississippi self emulsifying drug delivery system (SEDDS) of Indomethacin, International Journal of Research in Pharmacy and Science 2014; 4(2): 17-23. 34. Damineni S Penjuri S C B, and Nagaraju R. Standford Essay? formulation and evaluation of self emulsifying drug delivery system (SEDDS) of communism ibuprofen, International Journal of Pharmaceutical science and research 2014; 5(8): 3511-3519. 35. . Kumar S, Kumar S G, Kumar P, Sharma R. self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations, African Journal of Basic Applied Sciences 2012; 4 (1): 07-11. 36. Reddy M S, Reddy N S, Reddy SM. solubility Enhancement of Poorly Water Soluble Drug Efavirenz by Solid Self Emulsifying Drug Delivery Systems, International Journal of Pharma Research Review, 2014; 3(4): 20-28. 37. Amrutkar C, Salunkhe K, Chaudhari S. study on self nano emulsifying drug delivery system of poorly water soluble drug rosuvastatin calcium, World Journal of Pharmaceutical Research 2014; 3(4): 2137-2151.

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47. Woo J. S., Songb Y. K., Hong J. Y., Lim S. In Books? J., Kim C. K. (2008), Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in Standford Study healthy volunteers, European Journal of Pharmaceutical Sciences, 33: 159-165. 48. Mandawgade S. D., Sharma S., Pathak S., Patravale V. B. (2008), Development of SMEDDS using natural lipophile: Application to i??i??-Artemether delivery, International Journal of england Pharmaceutics, 362: 179-183. 49. Yi T., Wan J., Xu H., Yang X. (2008), Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose, European Journal of Pharmaceutical Sciences, 34: 274-280.

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53. Thakkar H., Nangesh J., Parmar M., Patel D. (2011), Formulation and characterization of lipid based drug delivery system of raloxifene microemulsion and self microemulsifying drug delivery system, Journal of Pharmacy and Bioallied Sciences, 3(3): 442-448. 54. Cirri M., Muraa P., Mora P. C. Suffrage England? (2007), Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems, International Journal of Pharmaceutics, 340: 84-91. 55. Patil P., Joshi P., Paradkar A. Prison Study Essay? (2004), Effect of Formulation Variables on Preparation and intertextuality examples in books, Evaluation of Prison Study Gelled Self-emulsifying Drug Delivery System (SEDDS) of Ketoprofen, AAPS PharmSciTech, 5(3) Article 42: 1-8. 56. Patel A. R., Vavia P. R. Pros? (2007), Preparation and In Vivo Evaluation of SMEDDS (Self-Microemulsifying Drug Delivery System) Containing Fenofibrate, The AAPS Journal, 9(3), Article 41: E344-E352. 57. Shen H., Zhong M. (2006), Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin, J Pharm Pharmacol., 58(9): 1183-1191. 58.

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68. Agarwal V., Siddiqui A., Ali H., Nazzal S. (2000), Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS), International Journal of Pharmaceutics, 366: 44-52. 69. Kim H. Standford Prison? J., Yoon K. A., Hahn M., Park E. S., Chi S. Mcdonalds? C., (2000), Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone, Drug Dev Ind Pharm., 26(5): 523-529. 70. Chen G. L., Lee F. Standford Prison Essay? Y. (1996), Validation of botanical method for Verapamil by high performance liquid chromatography, J Med Sci, 17(1): 16-23. 71.

Shah N.H., Carvajal M.T., Patel C.I., Infeld M.H., Malick A.W. (1994), Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, International Journal of Pharmaceutics, 106: 15-23. 74. Movie? Indian pharmacopeia. 75. Prison Study Essay? British pharmacopeia. 76. Bhagwat durgachara, D. souza I. development of self micro emulsifying drug delivery inhance dissolution rate of mississippi masala full telmisartain, IJDDR 2012,02(04);398-407. 77. Gaikwad G, Godbole M, potnos V, Daud A. Formulation and Study Essay, evaluation of self emulcifying drug delivery system of mississippi movie orlistat, Americal Journal Of Pharmtech Research 2012; 2 (6): 297-31. Search our thousands of Prison Study essays:

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